关键词: 人格解体障碍, 自我面孔识别, 反应速度

Abstract: Objective To explore the characteristics of self-processing and familiarity-processing in patients with depersonalization disorder. Methods Seventeen patients meeting the depersonalization disorder criterion of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-Ⅳ) and seventeen normal subjects matched for age, sex and level of education were recruited to participate in the self-face recognition test. All subjects were required to identify the identity of one certain face by pressing buttons using right hand respectively from a mixture of any two face features (self-famous, famous-stranger and self-stranger) and scrambled faces. The recognition speed to “self-face” and “other-face” were collected. The average recognition speed to the same kind of picture in different tasks was regarded as response time. Under each experimental condition, the reaction time to scrambled (control) pictures was taken as benchmark, which could be used to the reaction time ratio (corrected reaction time). Results Repeated analysis of variance (ANOVA) showed a significant main effect of group and intra group (F=20.57, P=0.001; F=3.67, P=0.031), interaction effect of group and picture was significant (F=10.75, P=0.001). Depersonalization disorder patients were significantly slower in recognizing the familiar pictures than strange pictures[(1.21±0.42) vs (1.06±0.21), P=0.001]. The reaction time ratio of both self-face[(1.12±0.30) vs (0.99±0.09)] and familiar-face[(1.21±0.42) vs (1.01±0.06)] in depersonalization disorder patients were slower than that in healthy controls (P<0.05). Pearson correlation analysis demonstrated that there was significantly positive correlations between the reacting time ratio of familiar pictures and total score of Cambridge Depersonalization Scale (CDS) (r=0.516,P=0.034)and familiarity score (r=0.498,P=0.042)in CDS. Conclusion These findings demonstrate that the reaction speed to familiar faces in depersonalization disorder patients is decreased,and further suggests that the familiarity-processing effect might be impaired in depersonalization disorder patients.

Key words: depersonalization disorder(DPD), self-face recognition, reaction speed