驯服进化的力量:酶和结合蛋白的定向进化及噬菌体展示技术——2018年诺贝尔化学奖简介

doi:10.3969/j.issn.1006-7795.2018.05.028

摘要/Abstract

摘要： 进化的力量在生物的多样性中得到了充分展现。2018年诺贝尔化学奖颁发给弗朗西丝·阿诺德（Frances H.Arnold）、乔治·史密斯（George P.Smith）和格雷戈里·温特（Gregory P.Winter）爵士，奖励他们研发出控制进化过程的方法，并利用这些方法造福人类。通过定向进化制造的酶可用于生产各类产品，包括生物燃料、药品等等。利用噬菌体展示技术生产的抗体能够对抗自身免疫性疾病，在有些情况下甚至能治愈转移性癌症。本文就3位获奖者的研究成果及其学术意义进行了介绍和总结。

关键词: 诺贝尔化学奖, 酶, 定向进化, 噬菌体展示, 抗体

Abstract: The power of evolution is revealed through the diversity of life. The Nobel Prize in Chemistry 2018 was awarded to Frances H. Arnold, George P. Smith and Sir Gregory P. Winter for the way they have taken control of evolution and used it for the greatest benefit to humankind. Enzymes developed through directed evolution are now used to produce biofuels and pharmaceuticals, among other things. Antibodies evolved using a method called phage display can combat autoimmune diseases, and in some cases, cure metastatic cancer. This article overviewed their research discoveries with the highlighted significance.

Key words: the 2018 Nobel Prize in Chemistry, enzymes, directed evolution, phage display, antibodies

曹立雪. 驯服进化的力量:酶和结合蛋白的定向进化及噬菌体展示技术——2018年诺贝尔化学奖简介[J]. 首都医科大学学报, 2018, 39(5): 770-777.

Cao Lixue. Harnessing the power of evolution:directed evolution of enzymes and binding protein & Phage display-Introduction of Nobel prize in Chemistry 2018[J]. Journal of Capital Medical University, 2018, 39(5): 770-777.

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