首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (5): 778-782.doi: 10.3969/j.issn.1006-7795.2018.05.029

• 拉斯克奖 • 上一篇    下一篇

2018年拉斯克奖(Ⅰ)——基础医学研究奖及医学特殊成就奖

牛欢, 程杉, 丁卫   

  1. 首都医科大学基础医学院生物化学与分子生物学系, 北京 100069
  • 收稿日期:2018-09-27 出版日期:2018-09-21 发布日期:2018-10-20
  • 通讯作者: 丁卫 E-mail:weiding@ccmu.edu.cn

The 2018 Lasker Awards(Ⅰ)-Basic Medical Research and Special Achievement in Medical Science

Niu Huan, Cheng Shan, Ding Wei   

  1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
  • Received:2018-09-27 Online:2018-09-21 Published:2018-10-20

摘要: 2018年度美国拉斯克奖获奖者名单公布。基础医学研究奖由洛克菲勒大学(Rockefeller University)的分子生物学家戴维·阿利斯(C.David Allis)和加州大学洛杉矶分校(The University of California,Los Angeles)的生物化学家迈克尔·格伦斯坦(Michael Grunstein)分享。两位学者发现并阐明了影响基因表达过程的组蛋白化学修饰机制,揭开了基因表达的隐秘控制层,从而开辟了现代表观遗传学的研究新领域。本次拉斯克医学特殊成就奖颁发给耶鲁大学(Yale University)的分子生物学与生物化学家琼·斯特恩兹(Joan A.Steitz),以表彰她在生物医学领域,特别是RNA生物学研究中卓越的领导才能和榜样作用。

关键词: 拉斯克奖, 组蛋白化学修饰, 基因表达, RNA生物学

Abstract: On September 11, 2018, the winners of Lasker Awards 2018 were announced. The Albert Lasker Basic Medical Research Award honored to molecular biologist C. David Allis from Rockefeller University and biochemist Michael Grunstein from the University of California. The two scientists have elucidated how gene expression are influenced by chemical modification of histones. Their discovery unveiled a previously hidden layer of gene control, therefore, established a novel field of the epigenetic control of gene expression.The 2018 Lasker Koshland Award for Special Achievement in Medical Science honored Joan A. Steitz, a molecular biologist and biochemist at Yale University. She contributed the leadership as well as a role model in biomedical science, predominantly in RNA biology.

Key words: Lasker Awards, chemical modification of histones, gene expression, RNA biology