首都医科大学学报 ›› 2019, Vol. 40 ›› Issue (3): 352-357.doi: 10.3969/j.issn.1006-7795.2019.03.006

• 中医基础和临床研究 • 上一篇    下一篇

抗肝癌I号方改善早、中期原发性肝细胞癌患者生活质量的临床研究

李牧婵1, 徐春军2, 王玉涛3, 王琮2   

  1. 1. 首都医科大学附属北京中医医院儿科, 北京 100010;
    2. 首都医科大学附属北京中医医院肝病科, 北京 100010;
    3. 首都医科大学附属北京中医医院教育处, 北京 100010
  • 收稿日期:2019-03-15 出版日期:2019-05-21 发布日期:2019-06-13
  • 通讯作者: 徐春军 E-mail:xu1409@sina.com
  • 基金资助:
    首都临床特色应用研究与成果推广(Z171100001017034)。

Clinical study on improving the quality of life in patients with early and middle stages hepatocellular carcinoma

Li Muchan1, Xu Chunjun2, Wang Yutao3, Wang Cong2   

  1. 1. Department of Pediatric, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;
    2. Department of Hepatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;
    3. Department of Education, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
  • Received:2019-03-15 Online:2019-05-21 Published:2019-06-13
  • Supported by:
    This study was supported by Capital Clinical Characteristic Application Research and Achievement Promotion (Z171100001017034).

摘要: 目的 探究抗肝癌I号方对早、中期原发性肝细胞癌患者生活质量改善情况。方法 纳入早、中期原发性肝细胞癌患者36例,口服抗肝癌I号方,连续治疗6个月。于治疗前、治疗3个月和治疗6个月时观察患者生活质量、中医证候改善情况。结果 ①生活质量评分比较:肝癌患者在口服抗肝癌I号方治疗期间,躯体功能、角色功能、情绪功能、认知功能、社会功能、总健康状况、疲倦、疼痛、气促、失眠、食欲丧失、便秘、腹泻评分持续改善,差异具有统计学意义(P<0.05)。②中医证候评分比较:中医证候量化总积分在治疗期间持续降低(P<0.05)。肝癌患者胁痛、胸闷善太息、食少、脘闷、情绪抑郁、嗳气、腹胀、面色晦暗、大便干结、口黏不欲饮、心烦、易怒、口苦、口干咽燥、溲赤、烦渴、耳鸣、膝软、失眠症状积分在治疗期间持续降低(P<0.05)。结论 初步观察到抗肝癌I号方能够提高早、中期原发性肝细胞癌患者生活质量、缓解临床症状,且长期服药效果较短期服药效果好。

关键词: 早、中期原发性肝细胞癌, 生活质量, 抗肝癌I号方

Abstract: Objective To observe the improvements of life quality of the patients with the early and middle stages hepatocellular carcinoma after treatment by using No.1 Anti Liver Cancer Prescription. Methods Thirty-six patients with early and middle stages hepatocellular carcinoma were included in this study. The patients took No.1 Anti Liver Cancer Prescription orally for 6 months continuously. The medical indicators including the quality of life and traditional Chinese medicine (TCM) syndromes were measured and recorded before the treatment, at the 3nd month of the treatment and at the end of the treatment.Results ① Comparison of quality of life scores:The scores of physical function, role function, emotional function, cognitive function, social function, general health status, fatigue, pain, shortness of breath, insomnia, loss of appetite, constipation and diarrhea were improved continuously. The difference was statistically significant (P<0.05). ② Comparison of TCM syndromes scores:Total score of TCM syndromes was decreased during the treatment period (P<0.05). The syndrome scores of hypochondriac pain, chest tightness and easy to sigh, loss of food-intake, stomach bilges, depressed, belching, abdominal distension, gloomy complexion, dry stool, mouth stick without desire to drink, upset, irritability, bitter taste, mouth and pharyngeal dry, yellow urine, polydipsia, tinnitus, knee weakness, and insomnia were decreased during the treatment period (P<0.05). Conclusion Preliminary observation, No.1 Anti Liver Cancer Prescription was able to improve the quality of life of patients with early and middle stages hepatocellular carcinoma. It can also alleviate clinical symptoms. The meditation effect of long-term treatment is better than that of short-term treatment.

Key words: early and middle stages hepatocellular carcinoma, quality of life, No.1 Anti Liver Cancer Prescription

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