人格解体患者认知功能及与临床症状和社会功能的相关性

doi:10.3969/j.issn.1006-7795.2020.01.012

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (1): 59-63.doi: 10.3969/j.issn.1006-7795.2020.01.012

• 精神疾病中西医结合治疗 • 上一篇下一篇

人格解体患者认知功能及与临床症状和社会功能的相关性

宋楠^1,2, 贾竑晓^1,2

1. 首都医科大学附属北京安定医院国家精神心理疾病临床研究中心精神疾病诊断与治疗北京市重点实验室, 北京 100088;
2. 首都医科大学人脑保护高精尖创新中心, 北京 100069

收稿日期:2019-12-02 出版日期:2020-02-21 发布日期:2020-02-13
通讯作者: 贾竑晓 E-mail:jhxlj@ccmu.edu.com
基金资助:
国家自然科学基金项目（81873398，81904120），首都卫生发展科研专项重点攻关项目（2018-1-2122），北京市医院管理中心"登峰"计划（DFL20191901）。

Cognitive impairment in patients with depersonalization disorder and its correlation with clinical symptoms and social function

Song Nan^1,2, Jia Hongxiao^1,2

1. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;
2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China

Received:2019-12-02 Online:2020-02-21 Published:2020-02-13
Supported by:
This study was supported by National Natural Science Foundation of China(81873398, 81904120),Capital Health Research and Development of Special Founding(2018-1-2122),Beijing Hospitals Authority' Ascent Plan(DFL20191901)

摘要/Abstract

摘要： 目的研究人格解体患者认知功能损害及与临床症状和社会功能的相关性。方法对符合精神障碍诊断标准与统计手册第5版（Diagnostic and Statistical Manual of Mental Disorders，Fifth Edition，DSM-V）中诊断标准以及剑桥人格解体量表（Cambridge Depersonalization Scale，CDS）评分≥70分的48例人格解体障碍患者，以及32例健康被试者分别采用连线测验（Trail Making Test A，TMTA）、符号编码、霍普金斯词语学习测验（Hopkins Verbal Learning Test Revised，HVLT-R）、简易视觉记忆测验（Brief Visuospatial Memory Test Revised，BVMT-R）、持续操作测验（Continuous Performance Test，CPT）和Stroop色-词测验进行认知功能评估，采用功能大体评定量表（Global Assessment Function，GAF）对社会功能进行评估，并采集一般人口学资料、临床信息后对相关信息进行分析。结果人格解体患者组与健康对照组在认知功能的TMTA（P=0.03）、HVLT-R（P=0.01）、BVMT-R（P=0.01）、Stroop测验（P=0.01）等方面差异有统计学意义；人格解体患者组内用药组与未用药组对认知功能的差异无统计学意义（P > 0.05）。人格解体患者组与健康被试组GAF评分差异有统计学意义（P=0.00）；认知功能中Stroop测验、CPT与临床症状呈负相关（r=-0.455，P < 0.05；r=-0.292，P < 0.05），TMTA与社会功能呈负相关（r=-0.300，P < 0.05），Stroop测验、BVMT-R与社会功能呈正相关（r=0.352，P < 0.05；r=0.344，P < 0.05），但关系密切程度偏弱。结论人格解体患者存在认知功能损害及社会功能下降，认知功能中注意/警觉能力与临床症状评分呈负相关，认知功能与社会功能有相关性，认知功能受损可导致社会功能下降。

关键词: 人格解体, 认知功能, 剑桥人格解体量表评分, 社会功能, 相关性

Abstract: Objective To study the impairment of cognitive function in patients with depersonalization disorder and its correlation with clinical symptoms and social function. Methods Forty eight who meet the diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition, DSM-V) and the Cambridge Depersonalization Scale (CDS) score of ≥ 70 patients with personality disintegration disorder and 32 healthy subjects used Trail Making Test A (TMTA), symbolic coding, Hopkins Verbal Learning Test Revised (HVLT-R), Brief Visuospatial Memory Test Revised (BVMT-R), Continuous Performance Test (CPT) and Stroop Color Test for cognitive function assessment, and collect general demographic and clinical information on relevant information perform analysis. Results There were significant differences in cognitive function of TMTA (P=0.03), HVLT-R (P=0.01), BVMT-R (P=0.01), and Stroop test (P=0.01) between the depersonalized patients and the healthy controls; There was no statistically significant difference in cognitive function between the medication group and the non-medication group in patients with disintegrated personality (P>0.05). There was a statistically significant difference in Global Assessment Function(GAF) scores on social function between the depersonalized patient group and the healthy test group (P=0.00); Stroop test and CPT test in cognitive function were negatively correlated with clinical symptoms (r=-0.455, P<0.05; r=-0.292, P<0.05), and TMAT test was negatively correlated with social function (r=-0.300, P<0.05), the Stroop test and the BVMT-R test were positively correlated with social function (r=0.352, P<0.05; r=0.344, P<0.05), but the relationship was weak. Conclusion Patients with personality disintegration have cognitive impairment and social function decline. Attention/alertness in cognitive function is negatively correlated with clinical symptom scores. There is a correlation between cognitive function and social function. Impaired cognitive function can lead to social function decline.

Key words: depersonalization disorder, cognitive function, Cambridge Depersonalization Scale, social function, relevance

中图分类号:

R149.91

宋楠, 贾竑晓. 人格解体患者认知功能及与临床症状和社会功能的相关性[J]. 首都医科大学学报, 2020, 41(1): 59-63.

Song Nan, Jia Hongxiao. Cognitive impairment in patients with depersonalization disorder and its correlation with clinical symptoms and social function[J]. Journal of Capital Medical University, 2020, 41(1): 59-63.

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人格解体患者认知功能及与临床症状和社会功能的相关性

Cognitive impairment in patients with depersonalization disorder and its correlation with clinical symptoms and social function

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