白细胞介素-21与复发性鼻息肉组织中IgE的相关性分析

doi:10.3969/j.issn.1006-7795.2020.02.009

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (2): 194-199.doi: 10.3969/j.issn.1006-7795.2020.02.009

• 慢性鼻窦炎伴鼻息肉的基础研究 • 上一篇下一篇

白细胞介素-21与复发性鼻息肉组织中IgE的相关性分析

杜崑, 郑铭, 王向东, 张罗

首都医科大学附属北京同仁医院耳鼻咽喉头颈外科, 北京 100730

收稿日期:2020-01-14 出版日期:2020-04-21 发布日期:2020-04-16
通讯作者: 张罗 E-mail:dr.luozhang@139.com
基金资助:
国家自然科学基金（81570894），北京市自然科学基金（7172054），北京市科技新星交叉学科合作项目（xxjc201712）。

Analysis for the relationship between interleukin-21 and tissue IgE in recurrent nasal polyps

Du Kun, Zheng Ming, Wang Xiangdong, Zhang Luo

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Received:2020-01-14 Online:2020-04-21 Published:2020-04-16
Supported by:
This study was supported by National Natural Science Foundation of China （81570894），Natural Science Foundation of Beijing （7172054）， Cross-disciplinary Collaborative Program of Beijing Science and Technology Nova （xxjc201712）.

摘要/Abstract

摘要： 目的研究在中国人IgE与慢性鼻窦炎伴鼻息肉（chronic rhinosinusitis with nasal polyps，CRSwNP）术后复发的关系，并进一步分析与复发性鼻息肉局部IgE产生相关的免疫分子。方法回顾性选取73例就诊于首都医科大学附属北京同仁医院并进行鼻内镜手术的CRSwNP患者和24例正常对照，术后随访3年以上，比较随访期间复发与未复发患者的临床特征、组织IgE、白细胞介素（interleukin，IL）-4、IL-21和CD40配体（CD40 ligand，CD40L）的表达情况，并分析IL-4、IL-21和CD40L与疾病复发和IgE的相关性。结果复发组患者合并哮喘的比例（30.3%）显著高于未复发组（10%）（P<0.05），且IgE浓度[257.40（143.00~ KU/L显著高于未复发组〖98.89（43.56~255.20）KU/L]（P<0.01），CD40L、IL-4和IL-21组间差异无统计学意义。73例患者的IL-21与CD40L（r=0.440，P<0.001）和IgE（r=0.290，P=0.01）均呈正相关，CD40L和IL-4在两组间均与组织IgE无相关性。在未复发组，IL-21与组织IgE无相关性，在复发组与IgE呈正相关（r=0.374，P=0.029）。结论鼻息肉组织中升高的总IgE浓度与术后疾病的复发相关，IL-21可能参与到了复发患者局部IgE产生的过程。

关键词: 慢性鼻窦炎伴鼻息肉, CD40配体, IgE, 白细胞介素-21, 术后复发

Abstract: Objective To investigate the relationship between tissue total IgE and postoperative recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP) and to further analyze the associated immunological molecules contributing to IgE production. Methods We retrospectively enrolled 73 CRSwNP patients and 24 healthy volunteers as a control group, and compared the clinical characteristics and the levels of tissue IgE, interleukin-4, IL-21 and CD40 ligand of the patients after endoscopic sinus surgery for 3 years. Sequentially, we analyzed the correlation between IgE and these immunological molecules. Results The presence of asthma comorbidity was significantly more frequent in recurrent CRSwNPs than non-recurrent group (30.3% vs 10%). The IgE levels in recurrent group[257.40(143.00-776.05)KU/L] was also significantly higher than that in non-recurrent group[98.89(43.56-255.20)KU/L], while the levels of CD40L, IL-4 and IL-21 showed no differences between the two groups. Among the 73 CRSwNPs (regardless of recurrence or non-recurrence), IL-21 significantly related to CD40L (r=0.440, P<0.001) and IgE(r=0.290,P=0.01). IL-21 significantly related to IgE in the recurrent group while not in non-recurrent group. CD40L and IL-4 showed no relationship with IgE neither in recurrent nor non-recurrent group. Conclusion Increased levels of IgE in nasal polyps related to the recurrence of CRSwNPs. IL-21, not CD40L and IL-4, might contribute to the IgE production in recurrent CRSwNPs.

Key words: chronic rhinosinusitis with nasal polyps, CD40L, IgE, interleukin-21, recurrence

中图分类号:

R765.4

杜崑, 郑铭, 王向东, 张罗. 白细胞介素-21与复发性鼻息肉组织中IgE的相关性分析[J]. 首都医科大学学报, 2020, 41(2): 194-199.

Du Kun, Zheng Ming, Wang Xiangdong, Zhang Luo. Analysis for the relationship between interleukin-21 and tissue IgE in recurrent nasal polyps[J]. Journal of Capital Medical University, 2020, 41(2): 194-199.

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白细胞介素-21与复发性鼻息肉组织中IgE的相关性分析

Analysis for the relationship between interleukin-21 and tissue IgE in recurrent nasal polyps

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