阿尔茨海默症的探索者——张晨教授

doi:10.3969/j.issn.1006-7795.2020.05.007

摘要/Abstract

摘要： 张晨教授，长期从事神经生物学的研究，发现兴奋性突触障碍是阿尔茨海默症早期病理变化，提出调控突触功能的干预新思路。作为院长带领首都医科大学基础医学院荣获"2019年全国教育系统先进集体"称号，入选青年北京学者和国家百千万人才工程并被授予"有突出贡献中青年专家"等称号。负责国家级研究课题十余项，包括国家杰出青年科学基金、国家优秀青年科学基金、国家重点研发计划（首席科学家）等。

关键词: 阿尔茨海默症, 突触功能失常, 突触调控新分子

Abstract: Dr. Zhang Chen, Professor and Dean, School of Basic Medical Sciences, Capital Medical University. As the most common neurodegenerative disease, the early causes of Alzheimer's disease (AD) remain unclear. Dr. Zhang has long been devoted himself to exploring the early neurological pathogenesis of AD. He found that short-term plasticity abnormality is an early pathological event in AD cases, and this deficit is caused by intracellular ryanodine receptor deficiency. Furthermore, using the two-photon method to study neural circuit activities on awake animals, he found that the prefrontal cortex incapable of encoding short-term memory is an earlier pathological event of AD compared with short-term plasticity deficits. Moreover, Dr. Zhang has identified several novel candidates (PTPRO, ABHD6 and others) functioning in the process of synapse formation and synaptic transmission, providing potential candidates for AD treatments.

Key words: Alzheimer's disease, synaptic dysfunction, new synaptic regulatory molecules

中图分类号:

R742

张晨. 阿尔茨海默症的探索者——张晨教授[J]. 首都医科大学学报, 2020, 41(5): 756-762.

Zhang Chen. An explorers of Alzheimer's disease——Professor Zhang Chen[J]. Journal of Capital Medical University, 2020, 41(5): 756-762.

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