脑卒中患者血浆中α-突触核蛋白及其寡聚体形成量变化的研究

doi:10.3969/j.issn.1006-7795.2013.06.009

首都医科大学学报 ›› 2013, Vol. 34 ›› Issue (6): 826-829.doi: 10.3969/j.issn.1006-7795.2013.06.009

• 帕金森病和卒中诊断与发病机制 • 上一篇下一篇

脑卒中患者血浆中α-突触核蛋白及其寡聚体形成量变化的研究

陈予东^1,2, 尹娜^1,2, 李昕^1,2, 杨巍巍^1,2, 李旭冉^1,2, 于顺^1,2

1. 首都医科大学宣武医院神经生物学研究室, 教育部神经变性病重点实验室, 北京 100053;
2. 北京市老年病医疗研究中心分子诊断实验室, 北京 100053

收稿日期:2013-10-18 出版日期:2013-12-21 发布日期:2013-12-13
通讯作者: 于顺 E-mail:yushun103@163.com
基金资助:
国家自然科学基金（81071014）；国家重点基础发展计划（973）计划（2011CB504101）；首都卫生发展科研专项课题（首发2011-1001-01）；国家科技支撑计划课题（2012BAI10B03）；北京市自然科学基金（7102076）。

Changes of α-synuclein and its oligomeric formation in plasmas of patients with stroke

CHEN Yudong^1,2, YIN Na^1,2, LI Xin^1,2, YANG Weiwei^1,2, LI Xuran^1,2, YU Shun^1,2

1. Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China;
2. Beijing Geriatric Medical and Clinical Center, Beijing 100053, China

Received:2013-10-18 Online:2013-12-21 Published:2013-12-13
Supported by:
This study was supported by the National Natural Science Foundation of China(81071014);National Basic Research and Development Program(973 Program) of China(2011CB504101);The Capital Health Research and Development Project(SHOUFA 2011-1001-01);National Science and Technology Support Program(2012BAI10B03);Natural Science Foundation of Beijing(7102076).

摘要/Abstract

摘要：

目的探讨脑卒中患者血浆中α-突触核蛋白（α-synuclein，α-Syn）含量的变化，以及血浆对α-Syn寡聚体形成的影响。方法收集2012年3月至5月首都医科大学宣武医院神经科诊断为脑卒中的住院患者50例，另收集年龄和性别与之相匹配的30例健康人群为对照组。用ELISA法检测各组人群血浆中的α-Syn总量及寡聚体形成量。结果脑卒中患者血浆α-Syn总含量及寡聚体形成量较对照组均有显著增加。结论脑卒中患者血浆中α-Syn含量增高增强其寡聚体的形成。

关键词: α-突触核蛋白, 脑卒中, 血浆

Abstract:

Objective To explore the changes of α-synuclein(α-Syn) level in plasma of patients with stroke, and observe the effect of plasma on the formation of oligomeric α-Syn. Methods A total of 50 hospitalized patients with stroke were recruited, they were diagnosed by neurologist of Xuanwu Hospital, Capital Medical University from March to May in 2012. A total of 30 people were recruited as the control group. ELISA was used to evaluate the total α-Syn and the formation of α-Syn oligomers in different groups. Results α-Syn oligomeric formation and total α-Syn level in the plasma of stroke patients was higher than that in controls'. Conclusion Plasma from stroke patients contained high level of total α-Syn and the plasma enhanced formation of oligomeric α-Syn.

Key words: α-synuclein, stroke, plasma

中图分类号:

R742.5

陈予东, 尹娜, 李昕, 杨巍巍, 李旭冉, 于顺. 脑卒中患者血浆中α-突触核蛋白及其寡聚体形成量变化的研究[J]. 首都医科大学学报, 2013, 34(6): 826-829.

CHEN Yudong, YIN Na, LI Xin, YANG Weiwei, LI Xuran, YU Shun. Changes of α-synuclein and its oligomeric formation in plasmas of patients with stroke[J]. Journal of Capital Medical University, 2013, 34(6): 826-829.

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脑卒中患者血浆中α-突触核蛋白及其寡聚体形成量变化的研究

Changes of α-synuclein and its oligomeric formation in plasmas of patients with stroke

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