缺血性脑卒中的脑功能与分子成像研究——卢洁教授

doi:10.3969/j.issn.1006-7795.2020.05.013

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (5): 788-794.doi: 10.3969/j.issn.1006-7795.2020.05.013

• 国家优秀青年科学基金获得者 • 上一篇下一篇

缺血性脑卒中的脑功能与分子成像研究——卢洁教授

单艺, 李静, 许潇尹

首都医科大学宣武医院放射科, 北京 100053

收稿日期:2020-08-18 出版日期:2020-10-21 发布日期:2020-10-26

Functional and molecular imaging of ischemic stroke——Professor Lu Jie

Shan Yi, Li Jing, Xu Xiaoyin

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

Received:2020-08-18 Online:2020-10-21 Published:2020-10-26

摘要/Abstract

摘要： 卢洁教授是国家"万人计划"科技创新领军人才、国家优秀青年基金获得者，长期围绕"缺血性脑卒中"这一国际前沿重大医学研究领域，运用新型一体化正电子发射型计算机断层摄影（positron emission computer tomography，PET）/磁共振成像（magnetic resonance imaging，MRI）融合脑功能与分子成像技术，引领国内本领域的发展。

关键词: 脑功能成像, 分子成像, 缺血性脑卒中

Abstract: Professor Lu Jie is the member of the National High-level Talents Program. She was supported by the National Science Fund for Outstanding Young Scholars. She has been focusing on the major problem of ischemic stroke and advancing the development of imaging in ischemic stroke by applying the new integrated positron emission computer tomography(PET)/magnetic resonance imaging(MRI) on brain function and molecular imaging.

Key words: functional imaging, molecular imaging, ischemic stroke

中图分类号:

R445

单艺, 李静, 许潇尹. 缺血性脑卒中的脑功能与分子成像研究——卢洁教授[J]. 首都医科大学学报, 2020, 41(5): 788-794.

Shan Yi, Li Jing, Xu Xiaoyin. Functional and molecular imaging of ischemic stroke——Professor Lu Jie[J]. Journal of Capital Medical University, 2020, 41(5): 788-794.

参考文献

[1] GBD 2016 Stroke Collaborators. Global, regional, and national burden of stroke, 1990-2016:A systematic analysis for the Global Burden of Disease Study 2016[J]. Lancet Neurol, 2019, 18(5):439-458.
[2] Wu S, Wu B, Liu M, et al. China Stroke Study Collaboration. Stroke in China:Advances and challenges in epidemiology, prevention, and management[J]. Lancet Neurol, 2019, 18(4):394-405.
[3] Nudo R J. Mechanisms for recovery of motor function following cortical damage[J]. Curr Opin Neurobiol, 2006, 16(6):638-644.
[4] Cramer S C. Repairing the human brain after stroke:mechanisms of spontaneous recovery[J]. Ann Neurol, 2008, 63(3):272-287.
[5] Zilles K, Amunts K. Individual variability is not noise[J]. Trends Cogn Sci, 2013, 17(4):153-155.
[6] Mueller S, Wang D, Fox M D, et al. Individual variability in functional connectivity architecture of the human brain[J]. Neuron, 2013,77(3):586-595.
[7] Li M, Wang D, Ren J, et al. Performing group-level functional image analyses based on homologous functional regions mapped in individuals[J]. PLoS Biol, 2019, 17(3):e2007032.
[8] Schmahmann J D, Ko R, MacMore J. The human basis pontis:motor syndromes and topographic organization[J]. Brain, 2004, 127(Pt 6):1269-1291.
[9] Lu J, Liu H, Zhang M, et al. Focal pontine lesions provide evidence that intrinsic functional connectivity reflects polysynaptic anatomical pathways[J]. J Neurosci, 2011, 31(42):15065-15071.
[10] Riedl V, Bienkowska K, Strobel C, et al. Local activity determines functional connectivity in the resting human brain:a simultaneous FDG-PET/fMRI study[J]. J Neurosci. 2014, 34(18):6260-6266
[11] Shang K, Cui B, Ma J, et al. Clinical evaluation of whole-body oncologic PET with time-of-flight and point-spread function for the hybrid PET/MR system[J]. Eur J Radiol, 2017,93:70-75.
[12] Ma Y, Gu Y, Tong X, et al. The Carotid and Middle Cerebral Artery Occlusion Surgery Study (CMOSS):a study protocol for a randomised controlled trial[J]. Trials,2016,17(1):544.
[13] Cui B, Zhang T, Ma Y, et al. Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease[J]. Eur J Nucl Med Mol Imaging, 2020, 47:1668-1677.
[14] Singhal A B, Wang X, Sumii T, et al. Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion[J]. J Cereb Blood Flow Metab, 2002, 22:861-868.
[15] Lu J, Dai G P, Egi Y, et al. Characterization of cerebrovascular responses to hyperoxia and hypercapnia using MRI in rat[J]. Neuroimage, 2009, 45(4):1126-1134.
[16] He Y, Xie F, Ye J, et al. 1-(4-[18F]Fluorobenzyl)-4-[(tetrahydrofuran-2-yl) methyl] piperazine:A novel suitable radioligand with low lipophilicity for imaging σ1 receptors in the brain[J]. J Med Chem, 2017, 60(10):4161-4172.

缺血性脑卒中的脑功能与分子成像研究——卢洁教授

Functional and molecular imaging of ischemic stroke——Professor Lu Jie

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