中药活性成分“合成生物学”创造与新药发现——高伟教授

doi:10.3969/j.issn.1006-7795.2020.05.012

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (5): 783-787.doi: 10.3969/j.issn.1006-7795.2020.05.012

• 国家优秀青年科学基金获得者 • 上一篇下一篇

中药活性成分“合成生物学”创造与新药发现——高伟教授

童宇茹¹, 张逸风², 沈思雨², 高伟^1,2

1. 首都医科大学药学院, 北京 100069;
2. 首都医科大学中医药学院, 北京 100069

收稿日期:2020-09-03 出版日期:2020-10-21 发布日期:2020-10-26
通讯作者: 高伟 E-mail:weigao@ccmu.edu.cn

“Synthetic biology” innovation of active natural products of traditional Chinese medicine and new drug discovery——Professor Gao Wei

Tong Yuru¹, Zhang Yifeng², Shen Siyu², Gao Wei^1,2

1. School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China;
2. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China

Received:2020-09-03 Online:2020-10-21 Published:2020-10-26

摘要/Abstract

摘要： 中药活性成分不仅是中医药发挥临床疗效的活性物质，还是现代创新药物开发的源泉，在医药领域具有广泛的应用价值。高伟教授团队致力于克隆鉴定中药活性成分生物合成途径上关键酶基因，解析其生物合成途径，并利用合成生物学方法人工重建代谢途径，构建细胞工厂发酵生产和改造活性成分。这一极具潜力的研究策略和创新型生产模式，在减少自然资源依赖、维护环境友好和实现大规模生产等方面具有重大科学价值。

关键词: 中药活性成分, 关键酶, 生源途径, 合成生物学, 生产, 活性评价

Abstract: The active natural products of traditional Chinese medicine are not only the active molecules that exert clinical curative effects, but also the source of developing modern innovative medicines. Professor Gao Wei's laboratory dedicates in cloning and identifying key enzymes in the biosynthetic pathway of active natural products, analyzing their biosynthetic pathways and applying synthetic biology methods to construct cell factories to produce or modify the active natural products. The promising research strategy and innovative production model have important scientific value for reducing dependence on natural resources, protecting natural environment and achieving large-scale production.

Key words: bio-active natural products of traditional Chinese medicine, key enzymes, biosynthetic pathway, synthetic biology, production, evaluation of pharmacological activity

中图分类号:

童宇茹, 张逸风, 沈思雨, 高伟. 中药活性成分“合成生物学”创造与新药发现——高伟教授[J]. 首都医科大学学报, 2020, 41(5): 783-787.

Tong Yuru, Zhang Yifeng, Shen Siyu, Gao Wei. “Synthetic biology” innovation of active natural products of traditional Chinese medicine and new drug discovery——Professor Gao Wei[J]. Journal of Capital Medical University, 2020, 41(5): 783-787.

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中药活性成分“合成生物学”创造与新药发现——高伟教授

“Synthetic biology” innovation of active natural products of traditional Chinese medicine and new drug discovery——Professor Gao Wei

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