中国女性轻度认知障碍的影响因素及其与绝经症状的关系

doi:10.3969/j.issn.1006-7795.2022.03.007

首都医科大学学报 ›› 2022, Vol. 43 ›› Issue (3): 369-374.doi: 10.3969/j.issn.1006-7795.2022.03.007

• 更年期妇科内分泌与生育力保护 • 上一篇下一篇

中国女性轻度认知障碍的影响因素及其与绝经症状的关系

许新¹, 阮祥燕^1*, 鞠蕊¹, 杨瑜¹, 程姣姣¹, 王志坤¹, Alfred O. Mueck^1,2

1.首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科, 北京 100026;
2.德国图宾根大学妇产医院妇女健康部与妇女健康研究中心,图宾根D-72076,德国

收稿日期:2022-02-27 出版日期:2022-06-21 发布日期:2022-06-01
基金资助:
北京市医院管理局“登峰”计划专项经费(DFL20181401),国家更年期保健特色专科建设单位[(2020)30]。

Relationship between mild cognitive impairment and menopausal symptoms in Chinese women

Xu Xin¹, Ruan Xiangyan^1*, Ju Rui¹, Yang Yu¹, Cheng Jiaojiao¹, Wang Zhikun¹, Alfred O. Mueck^1,2

1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing 100026, China;
2. Department of Women’s Health,University Women’s Hospital and Research Centre for Women’s Health,University of Tuebingen,Tuebingen D-72076,Germany

Received:2022-02-27 Online:2022-06-21 Published:2022-06-01
Contact: *E-mail:ruanxiangyan@ccmu.edu.cn
Supported by:
Beijing Municipal Administration of Hospitals' Ascent Plan(DFL20181401), National Menopause Health Care Specialist Construction Unit of China[(2020)30].

摘要/Abstract

摘要： 目的调查中国女性轻度认知障碍(mild cognitive impairment, MCI)的影响因素及其与各种典型绝经症状之间的关系。方法采用蒙特利尔认知评估量表(Montreal Cognitive Assessment , MoCA)评估150名志愿者的认知功能,将其中患有轻度认知障碍的61例患者作为病例组(MCI组),认知功能正常的89例患者作为对照组(Non-MCI组)。收集临床、社会人口学和人体测量学数据,用改良Kupperman评分表(Modified Kupperman Index, KMI)评估绝经症状。两组间比较应用t检验和χ²检验。采用二元Logistic回归模型筛选轻度认知功能障碍的危险因素。结果单因素分析显示,两组患者间年龄(P=0.001)、教育水平(P=0.001)、KMI评分(P <0.001)、失眠(P=0.033)与轻度认知功能障碍有关。多因素分析显示,对于年龄不超过55岁的患者,失眠(P=0.032)、头痛(P=0.021)是MCI的独立危险因素,高教育水平(P=0.004)是MCI的独立保护性因素。结论各种更年期症状与MCI之间明确关联,这可能为预防痴呆症提供了新的方向。

关键词: 轻度认知功能障碍, 绝经, 改良Kupperman指数, 蒙特利尔认知评估量表, 绝经症状

Abstract: Objective To investigate the relationship between mild cognitive impairment (MCI) and various typical menopausal symptoms in Chinese women. Methods A total of 150 volunteers were included in the study,and there were 61 cases(40.7%) in MCI group and 89 cases (59.3%) in non-MCI group. Montreal Cognitive Assessment (MoCA) was used to assess cognitive function. Clinical, sociodemographic and anthropometric data were collected, and menopausal symptoms were evaluated by Modified Kupperman Index (KMI). The two groups were compared by t-test and χ² inspection. Binary Logistic regression model was used to predict the risk factors of mild cognitive impairment. Results Univariate analysis showed that there were significant differences in age (P=0.001), education level (P=0.001), KMI score (P<0.001) and insomnia (P=0.033) between the two groups. Multivariate analysis found that, insomnia (P=0.032) and headache (P=0.021) were independent risk factors, while education (P=0.004) was independent protective risk factor for MCI in patients under 55 years. Conclusion We reported a clear association between various menopausal symptoms and MCI. This may provide novel direction for the prevention of dementia.

Key words: mild cognitive impairment, menopause, Modified Kupperman Index, Montreal Cognitive Assessment, menopausal symptoms

中图分类号:

许新, 阮祥燕, 鞠蕊, 杨瑜, 程姣姣, 王志坤, Alfred O. Mueck. 中国女性轻度认知障碍的影响因素及其与绝经症状的关系[J]. 首都医科大学学报, 2022, 43(3): 369-374.

Xu Xin, Ruan Xiangyan, Ju Rui, Yang Yu, Cheng Jiaojiao, Wang Zhikun, Alfred O. Mueck. Relationship between mild cognitive impairment and menopausal symptoms in Chinese women[J]. Journal of Capital Medical University, 2022, 43(3): 369-374.

参考文献

[1] 中国痴呆与认知障碍诊治指南写作组, 中国医师协会神经内科医师分会认知障碍疾病专业委员会. 2018中国痴呆与认知障碍诊治指南(五): 轻度认知障碍的诊断与治疗[J]. 中华医学杂志, 2018, 98(17): 1294-1301.
[2] Stute P, Wienges J, Koller A S, et al. Cognitive health after menopause: does menopausal hormone therapy affect it?[J]. Best Pract Res Clin Endocrinol Metab, 2021, 35(6): 101565.
[3] Anon. 2021 Alzheimer's disease facts and figures[J]. Alzheimers Dement, 2021, 17(3): 327-406.
[4] Su X N, Shang L, Xu Q L, et al. Prevalence and predictors of mild cognitive impairment in Xi'an: a community-based study among the elders[J]. PLoS One, 2014, 9(1): e83217.
[5] 张宏博, 徐勇, 陈彬, 等. 阿尔茨海默病患病率的Meta分析[J]. 中国老年学杂志, 2018, 38(9): 2157-2162.
[6] Ju R, Ruan X Y, Xu X, et al. Sexual dysfunction in Chinese women at different reproductive stages and the positive effect of hormone replacement therapy in the early postmenopause[J]. Eur J Contracept Reprod Health Care, 2021, 26(3): 246-254.
[7] Song M, Wang Y M, Wang R, et al. Prevalence and risks of mild cognitive impairment of Chinese community-dwelling women aged above 60 years: a cross-sectional study[J]. Arch Womens Ment Health, 2021, 24(6): 903-911.
[8] Lei Lei E, Ladha K, Mueller B, et al. Noncardiac determinants of death and intensive care morbidity in adult congenital heart disease surgery[J]. J Thorac Cardiovasc Surg, 2020, 159(6): 2407-2415.e2.
[9] 黄若燕, 唐牟尼, 马崔, 等. 广州市60岁及以上老人轻度认知障碍的患病率调查[J]. 中国神经精神疾病杂志, 2008, 34(9): 533-537.
[10] Hestiantoro A, Wiwie M, Shadrina A, et al. FSH to estradiol ratio can be used as screening method for mild cognitive impairment in postmenopausal women[J]. Climacteric, 2017, 20(6): 577-582.
[11] Xu W, Tan C C, Zou J J, et al. Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis[J]. J Neurol Neurosurg Psychiatry, 2020, 91(3): 236-244.
[12] Hung C M, Li Y C, Chen H J, et al. Risk of dementia in patients with primary insomnia: a nationwide population-based case-control study[J]. BMC Psychiatry, 2018, 18(1): 38.
[13] Vuralli D, Wattiez A S, Russo A F, et al. Behavioral and cognitive animal models in headache research[J]. J Headache Pain, 2019, 20(1): 11.
[14] Cheng Y J, Lin C H, Lane H Y. From menopause to neurodegeneration-molecular basis and potential therapy[J]. Int J Mol Sci, 2021, 22(16): 8654.

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中国女性轻度认知障碍的影响因素及其与绝经症状的关系

Relationship between mild cognitive impairment and menopausal symptoms in Chinese women

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