前庭导水管扩大患儿影像与听力结果分析

doi:10.3969/j.issn.1006-7795.2022.04.004

首都医科大学学报 ›› 2022, Vol. 43 ›› Issue (4): 535-539.doi: 10.3969/j.issn.1006-7795.2022.04.004

• 耳聋疾病:基础研究到临床诊疗 • 上一篇下一篇

前庭导水管扩大患儿影像与听力结果分析

杨亚利^1,2, 黄丽辉^3*, 程晓华³, 刘莎³

1.首都医科大学附属北京友谊医院耳鼻咽喉头颈外科,北京 100050;
2.首都医科大学耳聋疾病临床诊疗与研究中心,北京 100050;
3.首都医科大学附属北京同仁医院耳鼻咽喉头颈外科北京市耳鼻咽喉科研究所,北京 100005

收稿日期:2022-04-29 出版日期:2022-08-21 发布日期:2022-10-28
基金资助:
国家自然科学基金面上项目(82071064),首都卫生发展科研专项自主创新项目(首发2022-2-1092)。

Analysis of imaging and hearing results in children with enlarged vestibular aqueduct

Yang Yali^1,2, Huang Lihui^3*, Cheng Xiaohua³, Liu sha³

1. Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;
2. Clinical Center for Hearing Loss, Capital Medical University, Beijing 100050, China;
3. Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University;Beijing Institute of Otolaryngology-Head and Neck Surgery, Beijing 100005, China

Received:2022-04-29 Online:2022-08-21 Published:2022-10-28
Contact: *E-mail:huangpub@126.com
Supported by:
This study was supported by the National Natural Science Foundation of China(82071064),the Capital's Funds for Health Improvement and Research (CFH 2022-2-1092).

摘要/Abstract

摘要： 目的回顾性分析前庭导水管扩大患儿的耳部影像表现及新生儿听力筛查结果及听力测试结果,探讨单纯前庭导水管扩大及合并其他内耳畸形的患儿的新生儿听力筛查通过率及听力损失程度是否有差异。方法 2009年1月至2019年12月在首都医科大学附属北京同仁医院儿童听力诊断中心就诊,电子计算机断层扫描(computed tomography,CT)显示有前庭导水管扩大伴或不伴其他内耳畸形的患儿92例(182耳),入组者均接受过新生儿听力筛查。收集患儿新生儿听力筛查、听力学测试结果及耳部影像学资料。根据影像学表现分为3组:A组为单纯前庭导水管扩大;B组为Mondini畸形伴前庭导水管扩大及前庭池扩大即不完全分隔Ⅱ型(incomplete partition type Ⅱ,IP-Ⅱ);C组为前庭导水管扩大伴前庭池扩大或半规管畸形。采用卡方检验对比组间的新生儿听力筛查通过率;采用Kruskal-Wallis秩和检验对比组间听力损失程度。结果 92例患儿首次就诊年龄为1.5～65个月,其中男性47例(51.1%)、女性45例(48.9%)。182耳中,A组占40.11%(73/182)、B组占26.37%(48/182)、C组占33.52%(61/182),B+C组约占59.89%。3组新生儿听力筛查通过率比较,差异无统计学意义(χ²=1.122,P=0.571);伴与不伴Mondini畸形间比较,差异无统计学意义(χ²=0.401,P=0.526)。3组听力损失程度及伴与不伴Mondini畸形组间比较,差异均无统计学意义(P>0.05)。结论前庭导水管扩大合并其他内耳畸形约占60%;无论前庭导水管扩大伴与不伴其他内耳畸形,新生儿听力筛查通过率及听力损失程度均差异无统计学意义,提示前庭导水管扩大所致的迟发性听力损失与伴随的其他畸形类型无关。

关键词: 前庭导水管扩大, 新生儿听力筛查, Mondini畸形, 听力损失程度,不完全分隔Ⅱ型

Abstract: Objective To explore the differences in the pass rate of neonatal hearing screening and degree of hearing loss between the ears with simple enlarged vestibular aqueduct (EVA) and EVA accompanied by other inner ear malformations. Methods The objects of this study were children diagnosed with enlarged vestibular aqueduct by computed tomography in Children's Hearing Diagnosis Center, Beijing Tongren Hospital,Capital Medical University and accepted newborn hearing screening (NHS) from January 2009 to December 2019. There are a total of 182 ears of 92 cases. The results of their NHS, clinical hearing tests and imaging of ear were collected, and the children were grouped according to image performance. The ears in group A with EVA alone, group B with EVA and Mondini deformity (vestibular pool enlarged may be included simultaneously)(IP-Ⅱ), and group C with EVA and enlarged vestibular pool or semicircular canal malformation without Mondini malformation. The difference in the pass rate of NHS between different groups was analyzed with chi-square test. Kruskal Wallis rank sum test was used to compare the degree of hearing loss between different groups. Results The age of 92 patients is between 1.5-65.0 months, 47 males (51.1%) and 45 females (48.9%). There were 73 ears in group A(40.11%, 73/182),48 ears in group B(26.37%, 48/182), and 61 ears in group C(33.52%, 61/182). Group B and group C account for 59.89% in total. The pass rate of NHS showed no significant difference between A, B, and C groups (χ²=1.122,P=0.571), and between B and A+C groups (χ²=0.401,P=0.526).The difference of the degree of hearing loss between different group showed no statistical significance(P>0.05). Conclusion Most children (about 60%)enrolled in this study had EVA accompanied by other inner ear malformation. The pass rate of newborn hearing screening and the degree of hearing loss showed no significant difference between the groups. Whether vestibular aqueduct enlargement is accompanied by other inner ear malformations could lead to delayed hearing loss.

Key words: enlarged vestibular aqueduct, newborn hearing screening, Mondini deformity, the degree of hearing loss, incomplete partition type Ⅱ

中图分类号:

杨亚利, 黄丽辉, 程晓华, 刘莎. 前庭导水管扩大患儿影像与听力结果分析[J]. 首都医科大学学报, 2022, 43(4): 535-539.

Yang Yali, Huang Lihui, Cheng Xiaohua, Liu sha. Analysis of imaging and hearing results in children with enlarged vestibular aqueduct[J]. Journal of Capital Medical University, 2022, 43(4): 535-539.

参考文献

[1] Okumura T, Takahashi H, Honjo I, et al. Sensorineural hearing loss in patients with large vestibular aqueduct[J]. Laryngoscope, 1995, 105(3 Pt 1):289－293; discussion 293－294.
[2] Kaga K. Cochlear implantation in children with inner ear malformation and cochlear nerve deficiency[M]. Singapore: Springer, 2017.
[3] 倪道凤. 内耳畸形的分类[J]. 听力学及言语疾病杂志, 2019, 27(1):1－5.
[4] World Health Organization. With adaptations from report of the first informal consultation on future organization development for the prevention of deafness and hearing impairment[R]. Geneva: WHO,1997.
[5] Jack K, 韩德民, 莫玲燕. 临床听力学[M]. 北京: 人民卫生出版社, 2006.
[6] Valvassori G E, Clemis J D. The large vestibular aqueduct syndrome[J]. Laryngoscope, 1978, 88(5):723－728.
[7] Emmrich J V, Fatterpekar G M. Dilated dysplastic vestibule: a new computed tomographic finding in patients with large vestibular aqueduct syndrome[J]. J Comput Assist Tomogr, 2011, 35(6):674－678.
[8] Weichbold V, Nekahm-Heis D, Welzl-Mueller K. Universal newborn hearing screening and postnatal hearing loss[J]. Pediatrics, 2006, 117(4):e631－e636.
[9] Young N M, Reilly B K, Burke L. Limitations of universal newborn hearing screening in early identification of pediatric cochlear implant candidates[J]. Arch Otolaryngol Head Neck Surg, 2011, 137(3):230－234.
[10] Dedhia K, Kitsko D, Sabo D N, et al. Children with sensorineural hearing loss after passing the newborn hearing screen[J]. JAMA Otolaryngol Head Neck Surg, 2013, 139(2):119－123.
[11] 杨亚利, 黄丽辉, 程晓华, 等. 前庭导水管扩大患儿的发现途径与首诊年龄[J]. 临床耳鼻咽喉头颈外科杂志, 2014, 28(22):1754－1758.
[12] 孙宝春, 代志瑶, 黄莎莎, 等. GJB2、SLC26A4基因致病性突变与内耳CT表型关系的研究[J]. 中华耳科学杂志, 2014, 12(1):30－33.
[13] 朱庆文, 臧雯, 袁永一, 等. 内耳畸形相关SLC26A4基因的研究[J]. 临床耳鼻咽喉头颈外科杂志, 2012, 26(1):22－26.
[14] Fitoz S, Sennarog∨lu L, Incesulu A, et al. SLC26A4 mutations are associated with a specific inner ear malformation[J]. Int J Pediatr Otorhinolaryngol, 2007, 71(3):479－486.

[1]	冯颖, 时克, 王宪波. 肝硬化合并肠系膜上静脉栓塞患者2年预后预测模型的构建与验证[J]. 首都医科大学学报, 2023, 44(1): 107-114.
[2]	王平, 杨军, 王向东, 张罗. 黄芩苷对脂多糖诱导的人单核细胞THP-1的炎症反应的作用[J]. 首都医科大学学报, 2022, 43(6): 893-898.
[3]	李艳, 王麒淇, 张宇玲, 段甦, 张海波, 王向东, 蓝凤. 不同体质量指数的慢性鼻窦炎伴鼻息肉患者临床特征分析[J]. 首都医科大学学报, 2022, 43(6): 899-904.
[4]	李颖, 陈彪, 王乃利, 郝欣平. 人体内耳冰冻切片免疫组织化学染色技术探讨[J]. 首都医科大学学报, 2022, 43(6): 905-910.
[5]	史慕寒, 王冲, 王旻, 袁飞, 邢志敏, 袁晓培, 吴雨潇. 慢性鼻窦炎术后复发额窦炎患者额隐窝气房残留情况的影像及再手术结果分析[J]. 首都医科大学学报, 2022, 43(6): 911-918.
[6]	杨婧兴, 蔡超, 赵妍, 王向东, 张罗. 黄芩苷在呼吸道黏膜慢性炎症性疾病中的抗炎作用及机制研究进展[J]. 首都医科大学学报, 2022, 43(6): 919-923.
[7]	李彦如, 王慧君, 韩德民. 儿童睡眠呼吸障碍疾病的源头研究[J]. 首都医科大学学报, 0, (): 817-825.
[8]	王麒淇, 蓝凤, 王晶, 郝柳思琪, 李艳, 张罗. PCDH9影响过敏性鼻炎鼻黏膜上皮屏障功能的体外研究[J]. 首都医科大学学报, 0, (): 886-892.
[9]	杨紫荆, 赵春丽, 梁文琦, 陈钟壡, 柳柯, 龚树生. 线粒体去乙酰化蛋白SIRT3在噪声诱导隐匿性听力损失中的作用[J]. 首都医科大学学报, 2022, 43(4): 521-526.
[10]	刘珊, 郭瑞, 宋新雨, 于倩茹, 陈钟壡, 梁文琦, 滕琪, 龚树生, 柳柯. 后半规管途径导入不同血清型腺相关病毒转染小鼠耳蜗内毛细胞的效果比较[J]. 首都医科大学学报, 2022, 43(4): 527-534.
[11]	冯蓉, 刘韵, 王国鹏, 龚树生. 内淋巴囊减压联合三个半规管填塞术对难治性梅尼埃病的眩晕疗效分析[J]. 首都医科大学学报, 2022, 43(4): 540-545.
[12]	夏宁, 聂秀红, 王昊, 樊晓君. 支气管哮喘合并OSA与冠心病发病率的相关性研究[J]. 首都医科大学学报, 2022, 43(1): 138-142.
[13]	赵之玥, 张罗. 胸怀祖国放眼世界,探索慢性鼻病奥秘——张罗教授[J]. 首都医科大学学报, 2020, 41(5): 742-747.
[14]	王慧君, 王东博. 四十载风雨兼程,开辟学科发展新模式——中国工程院院士韩德民教授[J]. 首都医科大学学报, 2020, 41(5): 800-804.
[15]	王敏, 李颖, 王向东, 张罗. IL-23在慢性鼻窦炎中的表达和作用[J]. 首都医科大学学报, 2020, 41(2): 178-182.

前庭导水管扩大患儿影像与听力结果分析

Analysis of imaging and hearing results in children with enlarged vestibular aqueduct

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价