丘脑底核脑深部电刺激对帕金森患者非运动症状长期疗效研究进展

doi:10.3969/j.issn.1006-7795.2025.04.023

摘要/Abstract

摘要： 脑深部电刺激(deep brain stimulation, DBS)作为近40年来飞速发展的神经外科干预手段，如今已广泛应用于运动障碍以及神经精神疾病的治疗，其中，丘脑底核脑深部电刺激(subthalamic nucleus deep brain stimulation, STN-DBS）尤以突出，在药物疗效减退的帕金森病（Parkinson's disease, PD）患者中，其对震颤、僵直、运动迟缓等运动症状的改善，以及对运动并发症的管理作用均获得广泛认可与应用。然而，STN-DBS对PD患者非运动症状（non-motor symptoms, NMS）的长期疗效仍存在争议，相关问题亦是当前学术界研究的热点。鉴于此，本文系统综述STN-DBS对PD患者各类NMS的长期影响、潜在机制以及未来研究方向，以便深入解析STN-DBS对人脑及疾病的作用机制，为完善临床诊疗提供理论支撑和实践参考。

关键词: 帕金森病, 丘脑底核, 脑深部电刺激, 认知功能, 情感障碍, 自主神经功能障碍

Abstract: Deep brain stimulation (DBS) has witnessed rapid advancement as a neurosurgical intervention over the past four decades, addressing movement disorders and a spectrum of neuropsychiatric conditions. Notably, subthalamic nucleus deep brain stimulation (STN-DBS) is widely implemented in the management of Parkinson's disease（PD）patients experiencing refractory motor fluctuations and complications, and has shown promise in ameliorating non-motor symptoms (NMS). However, the long-term efficacy of STN-DBS on NMS remains a subject of scholarly discourse. This review endeavors to synthesize current knowledge regarding the long-term impacts, underlying mechanisms, and future research directions of STN-DBS in the context of NMS in Parkinson's disease.

Key words: Parkinson's disease, subthalamic nucleus, deep brain stimulation, cognitive function, affective disorders, autonomic dysfunction

中图分类号:

R742.5

蒋忱冠, 刘演, 杨舟, 李秉心, 张建国, 石林. 丘脑底核脑深部电刺激对帕金森患者非运动症状长期疗效研究进展[J]. 首都医科大学学报, 2025, 46(4): 733-741.

Jiang Chenguan, Liu Yan, Yang Zhou, Li Bingxin, Zhang Jianguo, Shi Lin. Research progress on the long-term effects of subthalamic nucleus deep brain stimulation on non-motor symptoms in Parkinson's disease[J]. Journal of Capital Medical University, 2025, 46(4): 733-741.

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