严重急性呼吸综合征患者中性粒细胞CD11b的变化及意义

首都医科大学学报 ›› 2006, Vol. 27 ›› Issue (1): 87-89.

严重急性呼吸综合征患者中性粒细胞CD11b的变化及意义

张霖, 聂秀红, 刘明芳

首都医科大学宣武医院呼吸内科

收稿日期:2005-01-10 修回日期:1900-01-01 出版日期:2006-02-24 发布日期:2006-02-24

Changes of Neutrophil CD11b in Patients with SARS and Its Clinical Significance

Zhang Lin, Nie Xiuhong, Liu Mingfang

Department of Pulmonology, Xuanwu Hospital, Capital University of Medical Sciences

Received:2005-01-10 Revised:1900-01-01 Online:2006-02-24 Published:2006-02-24

摘要/Abstract

摘要： 目的通过观察严重急性呼吸综合征(severe acute respiratory syndrome,SARS)患者病程中中性多型核粒细胞(PMN)表面CD11b的表达强度,初步探讨PMN的黏附功能在SARS病程中的变化及意义.方法应用流式细胞仪检测86例SARS患者外周血PMN的CD11b表达强度,根据采血时病程及病情将患者分为3组,44例符合出院标准的患者为出院组,肺部阴影明显吸收的33例为恢复组(其中18例为普通型,15例为重症型),肺部阴影加重且符合重症型的患者9例为重症型进展组.另有25例健康体检者为正常对照组,比较各组CD11b表达强度的差异.恢复组有13例、重症进展组有4例间隔1周复查CD11b,比较2种情况下CD11b的变化趋势.结果恢复组CD11b的表达显著高于正常对照组与出院组(P＝0.000,0.003),正常对照组与出院组CD11b表达差异无统计学意义(P=0.066).重症进展9例患者与恢复组内的15例重症患者及正常组比较,重症进展组CD11b显著高于正常对照组(P=0.000),但与重症恢复组间差异无统计学意义(P=0.997).恢复组13例间隔1周检测CD11b的结果较复查前明显下降(P=0.000);重症进展组4例间隔1周检测CD11b,其均值较复查前增加.结论处于恢复阶段SARS患者的PMN仍有较高的黏附功能;其动态变化可反映SARS患者病情的发展趋势.

关键词: 严重急性呼吸综合征, 中性粒细胞, 黏附分子, CD11b

Abstract: Objective To investigate the changes of CD11b expression of neutrophil in patients with SARS and its significance.Methods The expressions of CD11b in peripheral blood were quantitatively analyzed by flow cytometry in 86 SARS patients.The patients were divided into 3 groups,including 44 cases of hospital discharge group,33 cases of recovery group(18 cases of common type SARS and 15cases of severe type SARS) and 9 cases of deteriorated group.25 healthy individuals served as the control.CD11b of 13 cases in recovery group and 4 cases in deteriorated group were analyzed again 1 week later.Results The expression of CD11b in the recovery group was significantly higher than that in control group and hospital discharge group(P=0.000,0.003).No significant difference was observed between hospital discharge group and control group(P=0.066).Compared with the expression of CD11b among 9 cases of deteriorated group,15 cases of severe type SARS patients in recovery group and control group,the expression of CD11b in deteriorated group was significantly higher than that in control group(P=0.000).There was no significant difference between deteriorated group and severe type patients in recovery group(P=0.997).The CD11b expression of 13 cases in recovery group was greatly decreased 1 week later(P=0.000).The mean level of CD11b expression of 4 cases in deteriorated group was higher than that 1 week before.Conclusion The adhesive function of PMN is higher in the recovery stage of SARS patients.The dynamic changes of CD11b expression can reflect the prognosis of SARS.

Key words: severe acute respiratory syndrome, neutrophil, adhesive molecule, CD11b

中图分类号:

R563.1

张霖;聂秀红;刘明芳. 严重急性呼吸综合征患者中性粒细胞CD11b的变化及意义[J]. 首都医科大学学报, 2006, 27(1): 87-89.

Zhang Lin;Nie Xiuhong;Liu Mingfang. Changes of Neutrophil CD11b in Patients with SARS and Its Clinical Significance[J]. Journal of Capital Medical University, 2006, 27(1): 87-89.

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