Abstract: Objective To evaluate the therapeutic effect of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma(GHPA) and analyze the correlative factors influencing the effect. Methods The clinical data of 106 patients who underwent transsphenoidal microsurgery for GHPA were retrospectively analyzed. The tumors were classified according to tumor size, preoperative GH levels, and invasion etc. Based on the criterion of cure of acromegaly, postoperative hormone level and imaging examination were used to evaluate the post-operative outcomes. Results Total remission rate was 72.6%, and grades Ⅰ, Ⅱ, Ⅲ, and Ⅳ adenomas were 84.2%, 82.6%, 64.7%, and 14.4%, respectively. But according to Knosp grading,the remission rate of 0~4 grade were 89.7%, 80.6%, 66.7%, 45.5% and 0.0%, respectively. Conclusion The prognoses were related to the size of the adenomas, the preoperative level of GH and invasiveness of GH-secreting adenomas.

Key words: pituitary adenomas, acromegaly, transsphenoidal surgery, growth hormone