Efficacy and safety of ticagrelor combined with primary PCI in elderly patients with ST-elevated acute myocardial infarction

doi:10.3969/j.issn.1006-7795.2015.01.014

Abstract

Abstract: Objective To observe the efficacy and safety of ticagrelor combined with primary percutaneous coronary intervention (PCI) in elderly patients with ST-segment elevated myocardial infarction (STEMI). Methods Totally 113 elderly patients with STEMI were divided into two groups. Patients in ticagrelor group were given aspirin 300 mg/ticagrelor 180 mg; and those in clopidogrel group were given aspirin 300 mg/clopidogrel 600 mg before primary PCI. No-reflow events and thrombolysis in myocardial infarction (TIMI) blood flow in coronary artery after primary PCI, major adverse cardiovascular events(MACE) within one month, bleeding events, dyspnea and malignant ventricular arrhythmia were detected. Results The incidence of no-reflow and MACE of ticagrelor group was significantly lower than that in clopidogrel group (P<0.05). There was no significant difference in bleeding events and malignant ventricular arrhythmia between the two groups. Conclusion Ticagrelor combined with primary PCI in treatment of the elderly patients with STEMI were effective and safe.

Key words: ticagrelor, clopidogrel, antiplatelet therapy, ST-segment elevated myocardial infarction, percutaneous coronary artery intervention

CLC Number:

R542.2

Xu Ji, Hua Qi, Hu Shaodong, Liu Zhi, Li Boyu, Sang Cheng, Xia Jinggang. Efficacy and safety of ticagrelor combined with primary PCI in elderly patients with ST-elevated acute myocardial infarction[J]. Journal of Capital Medical University, 2015, 36(1): 73-77.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.01.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I1/73

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