Amplitude of low-frequency fluctuation of functional magnetic resonance imaging in mild cognitive impairment

doi:10.3969/j.issn.1006-7795.2018.02.002

Abstract

Abstract: Objective To study the changes of amplitude of low-frequency fluctuation (ALFF) of resting-state functional magnetic resonance imaging (rs-fMRI) in patients with mild cognitive impairment (MCI). Methods Fifty patients with MCI and 50 normal controls (NC) were recruited. All subjects were examined by functional MRI (fMRI) to analyze the difference of resting-state brain function between MCI and normal controls based on the ALFF method. Results Compared with the normal controls, ALFF in the bilateral parahippocampal gyrus, bilateral caudate nucleus, left putamen and left insula decreased in MCI group. No increased region was found.Conclusion The activity of bilateral parahippocampal gyrus and some cognitive related subcortical structures decreased in the resting-state fMRI.

Key words: mild cognitive impairment, Alzheimer's disease, resting-state functional magnetic resonance imaging, amplitude of low-frequency fluctuation

CLC Number:

R445

Fan Xiang, Yang Yanhui, Jia Xiuqin, Lu Jie, Li Kuncheng. Amplitude of low-frequency fluctuation of functional magnetic resonance imaging in mild cognitive impairment[J]. Journal of Capital Medical University, 2018, 39(2): 163-166.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.02.002

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I2/163

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