Reproducibility of quantitative flow assessment of intracranial arteries of anterior cerebral circulation of healthy subjects using 4D flow imaging

doi:10.3969/j.issn.1006-7795.2018.02.001

Abstract

Abstract: Objective To investigate the reproducibility of quantitative flow assessment of healthy subjects using 4D flow imaging. Methods Four healthy volunteers were enrolled in this study. Four-dimensional flow magnetic resonance (MR) imaging were acquired and rescanned for circle of Willis using the same protocol and parameters. The flow data were post-processed with a prototype flow analysis software 4D Flow. The hemodynamic parameters at the biateral locations including the inlet of the intracranial portion of the internal carotid artery (ICA), the siphon of the ICA, the distal segment of the ICA, the beginning and the proximal segment of the middle cerebral artery (MCA), and the proximal segment of the anterior cerebral artery (ACA) were calculated. The average vessel area, average velocity, maximum flow velocity, and average net flow rate obtained from the first imaging and rescanned imaging were compared. Velocity vectors, streamlines, and particle traces maps were visualized. Results The comparison of hemodynamic parameters showed that significant difference was found in all parameters of right ICA (RICA) siphon, the maximum flow velocity of left ICA (LICA) siphon, bilateral ICA inlet segment, the beginning of bilateral MCA and ACA, and the proximal segment of right MCA, as well as the average area of the proximal segment of bilateral MCA and the beginning of left ACA, and the average velocity of the beginning of left ACA between two scanned images. In one subject, the heartbeats of two scans showed obvious change; and the maximum flow velocity was found to vary obviously. In the siphon segment of ICA, it was also found that there was intense variety in maximum flow velocity between two examinations. Conclusion The reproducibility of 4D flow imaging in quantitative flow assessment of intracranial arteries was acceptable. However, the reproducibility of 4D flow imaging will need further confirmation under different heartbeats conditions and for locations with complex hemodynamics status in future studies.

Key words: magnetic resonance imaging, intracranial arteries, hemodynamics, 4D flow imaging, reproducibility

CLC Number:

R445

Sui Binbin, Gao Peiyi, Lin Yan, Zhao Haiqing, Song Ligang. Reproducibility of quantitative flow assessment of intracranial arteries of anterior cerebral circulation of healthy subjects using 4D flow imaging[J]. Journal of Capital Medical University, 2018, 39(2): 157-162.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.02.001

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I2/157

References

[1] Markl M, Frydrychowicz A, Kozerke S, et al. 4D flow MRI[J]. J Magn Reson Imaging, 2012, 36(5):1015-1036.
[2] Stankovic Z, Allen B D, Garcia J, et al. 4D flow imaging with MRI[J]. Cardiovasc Diagn Ther, 2014, 4(2):173-192.
[3] Markl M, Schnell S, Barker A J. 4D flow imaging:current status to future clinical applications[J]. Curr Cardiol Rep, 2014, 16(5):481.
[4] Gimbrone M A Jr, Topper J N, Nagel T, et al. Endothelial dysfunction, hemodynamic forces, and atherogenesis[J]. Ann N Y Acad Sci, 2000, 902:230-239.
[5] Gimbrone M A Jr,Garcia-Cardeña G. Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis[J]. Cardiovasc Pathol, 2013, 22(1):9-15.
[6] Burris N S, Hope M D. 4D flow MRI applications for aortic disease[J]. Magn Reson Imaging Clin N Am, 2015, 23(1):15-23.
[7] Vasanawala S S, Hanneman K, Alley M T, et al. Congenital heart disease assessment with 4D flow MRI[J]. J Magn Reson Imaging, 2015, 42(4):870-886.
[8] Harloff A, Zech T, Wegent F, et al. Comparison of blood flow velocity quantification by 4D flow MR imaging with ultrasound at the carotid bifurcation[J]. AJNR Am J Neuroradiol, 2013, 34(7):1407-1413.
[9] 邬冬芳,何文, 时传迎, 等. 超声造影检查在脑血管疾病中的应用[J].首都医科大学学报, 2015, 36(5):814-819.
[10] Ansari S A, Schnell S, Carroll T, et al. Intracranial 4D flow MRI:toward individualized assessment of arteriovenous malformation hemodynamics and treatment-induced changes[J]. AJNR Am J Neuroradiol, 2013, 34(10):1922-1928.
[11] Futami K, Sano H, Misaki K, et al. Identification of the inflow zone of unruptured cerebral aneurysms:comparison of 4D flow MRI and 3D TOF MRA data[J]. AJNR Am J Neuroradiol, 2014, 35(7):1363-1370.
[12] Frangos S G Gahtan V, Sumpio B. Localization of atherosclerosis:role of hemodynamics[J]. Arch Surg, 1999, 134(10):1142-1149.
[13] 隋滨滨,高培毅, 林燕, 等. 4D血流MR成像评估颅内动脉血流动力学状态的实验研究[J].国际医学放射学杂志, 2017, 40(6):641-646.
[14] Sui B, Gao P, Lin Y, et al. Hemodynamic parameters distribution of upstream, stenosis center, and downstream sides of plaques in carotid artery with different stenosis:a MRI and CFD study[J]. Acta Radiol, 2015, 56(3):347-354.
[15] Harloff A. Carotid plaque hemodynamics[J]. Interv Neurol, 2012, 1(1):44-54.
[16] Yang F, Liu L, Li M, et al. Pattern of cerebrovascular atherosclerotic stenosis in older Chinese patients with stroke[J]. J Clin Neurosci, 2013, 20(7):979-983.
[17] 刘然,华扬,贾凌云,等.超声检测吸烟与颅内动脉狭窄相关性的多中心研究结果分析[J].中国脑血管病杂志,2017,14(6):297-301,312.
[18] 张潇怡,李颖,周志可,等.老年不同类型分水岭脑梗死危险因素及颅内血管病变特点研究[J].中国医科大学学报,2016,45(12):1128-1132.