Graph theory-based analysis of brain functional networks in children with Gaucher disease

doi:10.3969/j.issn.1006-7795.2018.02.003

Abstract

Abstract: Objective To investigate the topological properties of brain functional networks in children with Gaucher disease (GD) and analyze their correlation with clinical parameters. Methods Sixteen children diagnosed as GD and sixteen age-and sex-matched healthy controls (HCs) were recruited. 3DT1-weighted anatomical images and resting state functional magnetic resonance imaging (MRI) data of all participants were obtained. A two sample t-test was used to analyze the differences between the children with type 1 GD and HCs. The Pearson test was used to analyze the correlation between the altered properties and the clinical parameters. Results Compared with HCs, no significant alterations of global topological properties were found in GD patients. Right middle frontal gyrus also showed decreased nodal degree, and right middle frontal gyrus, left inferior frontal gyrus/orbitofrontal gyrus, and left superior parietal gyrus/inferior parietal gyrus/precuneus/angular gyrus showed decreased efficiency. All the functional regions of interests (ROIs) were components of executive control network (ECN). Two brain hubs lost and they were left thalamus and precuneus. Three brain hubs appeared and they were right thalamus/caudate/putamen, right angular gyrus/middle occipital gyrus and right inferior parietal lobule. Conclusion The efficiency of global topological properties in children with GD is preserved. Only functional ROIs within ECN showed decreased performance and a few brain hubs reorganized. Our result provided neuroimaging evidence for brain functional impairment in children with GD.

Key words: Gaucher disease, magnetic resonance imaging, graph theory

CLC Number:

R445.2

Zhang Miao, Wang Shengpei, Hu Di, Kang Huiying, He Huiguang, Peng Yun. Graph theory-based analysis of brain functional networks in children with Gaucher disease[J]. Journal of Capital Medical University, 2018, 39(2): 167-172.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.02.003

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I2/167

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