Progress in mRNA vaccine—The 2021 Lasker Clinical Medicine Research Award

doi:10.3969/j.issn.1006-7795.2021.05.033

Abstract

Abstract: The 2021 Lasker Clinical Medicine Research Award is awarded to biochemist Katalin Karikó and immunologist Drew Weissman who have made significant contributions to the research and development of mRNA vaccines. However, the current understanding of such vaccines is still insufficient. Messenger RNA (mRNA) vaccine is to synthesize mRNA sequence encoding a given specific antigen in vitro, which can be delivered into the body and express the corresponding protein. In turn, the antigenic protein encoded by the mRNA vaccine is able to induce an immune response against the specific antigen protein, which can prevent and treat a certain disease. As a new type of vaccine, mRNA vaccine has the characteristics of high transfectional efficiency, strong ability for immune stimulation, good safety, rapid industrialization and low cost, etc. The application of mRNA vaccine in the prevention and theraputis of some infectious diseases and cancers has shown its unique advantages.

Key words: mRNA vaccine, infectious diseases, tumor, clinical trials

CLC Number:

Q522⁺.2

Chen Yan, Sun Ying. Progress in mRNA vaccine—The 2021 Lasker Clinical Medicine Research Award[J]. Journal of Capital Medical University, 2021, 42(5): 893-889.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.05.033

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I5/893

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