Mechanisms of DNA repair for the maintenance of genome stability in cells——introduction of 2015 Nobel Prize in Chemistry

doi:10.3969/j.issn.1006-7795.2015.05.032

Abstract

Abstract: The 2015 Nobel Prize in Chemistry was honored to three scientists of Tomas Lindahl from Sweden, Paul Modrich from United States and Aziz Sancar with both American and Turkish nationalities for their contributions in revealing the mechanisms of DNA repair in cells. This article overviewed their research discoveries with the highlighted significance. Meanwhile, as DNA repair is closely connected to cell genome stability, especially under disease conditions, we commented the impact and perspective of high-throughput sequencing and the omic technologies on the future studies in biomedical fields.

Key words: Nobel Prize in Chemistry, DNA repair, genome stability, high-throughput sequencing

Kong Lu, Ding Wei. Mechanisms of DNA repair for the maintenance of genome stability in cells——introduction of 2015 Nobel Prize in Chemistry[J]. Journal of Capital Medical University, 2015, 36(5): 823-828.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.05.032

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I5/823

References

[1] Lindahl T. Instability and decay of the primary structure of DNA[J]. Nature, 1993,362: 709-715.
[2] Lindahl T, Nyberg B. Rate of depurination of native deoxyribonucleic acid[J]. Biochemistry,1972,11: 3610-368.
[3] Lindahl T. New class of enzymes acting on damaged DNA[J]. Nature, 1976, 259(5538): 64-66.
[4] Adams A, Lindahl T. Epstein-Barr virus genomes with properties of circular DNA molecules in carrier cells[J]. Proc Natl Acad Sci USA, 1975,72(4):1477-1481.
[5] Mol C D, Arvai A S, Slupphaug G, et al. Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis[J]. Cell, 1995, 80(6): 869-878
[6] Lindahl T, Wood R D. Quality control by DNA repair[J]. Science, 1999,286: 1897-1905.
[7] Wagner R Jr, Meselson M. Repair tracts in mismatched DNA heteroduplexes[J]. Proc Natl Acad Sci U S A, 1976, 73(11): 4135-4139.
[8] Lu A L, Clark S, Modrich P. Methyl-directed repair of DNA base-pair mismatches in vitro[J]. Proc Natl Acad Sci U S A, 1983,80(15): 4639-4643.
[9] Lahue R S, Au K G, Modrich P. DNA mismatch correction in a defined system[J]. Science, 1989,245(4914): 160-164.
[10] Kelner A. Effect of Visible Light on the Recovery of Streptomyces Griseus Conidia from Ultra-violet Irradiation Injury[J]. Proc Natl Acad Sci U S A, 1949, 35(2): 73-79.
[11] Sancar A, Rupert C S. Cloning of the phr gene and amplification of photolyase in Escherichia coli[J]. Gene, 1978, 4(4): 295-308.
[12] Sancar A, Rupp W D. A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region[J]. Cell, 1983. 33(1): 249-260.
[13] Aboussekhra A, Egly J M, Wood R D. et al. Mammalian DNA nucleotide excision repair reconstituted with purified protein components[J]. Cell, 1995,80(6): 859-868.
[14] Davidsen T, Tønjum T. Meningococcal genome dynamics[J]. Nat Rev Microbiol, 2006, 4(1): 11-22.
[15] Lindahl T, Nyberg B. Rate of depurination of native deoxyribonucleic acid[J]. Biochemistry, 1972, 11(19): 3610-3618
[16] Hu J, Adar S, Selby C P,et al. Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution[J]. Genes Dev, 2015, 29(9):948-960.
[17] Zhou Z X, Zhang M J, Peng X, et al. Mapping genomic hotspots of DNA damage by a single-strand-DNA-compatible and strand-specific ChIP-seq method[J]. Genome Res,2013,23(4):705-715.
[18] Zhang H H, Zang Y J, Sun Y, et al. A new approach utilizing real-time qPCR to detect in vitro base excision repair[J]. DNA Repair (Amst),2010,14;9(8):898-906.
[19] Wiggans A J, Cass G K, Bryant A, et al. Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer[J]. Cochrane Database Syst Rev, 2015,5:CD007929.