Abstract: Objective To establish the animal model and observe the therapeutic effect of Qi Huang Ju Yu Fang on limb arterial occlusion in rats. Methods Totally 60 Wistar rats were fed with high fat diet combined with the method of saphenous artery intima injury to make the (arteriosclerosis occlusive disease,ASO) model of rats; to observe the therapy effect in the different concentration groups on serum lipids, blood rheology indexes of the rats compared with Cilostazol as control group. Results Serum total cholesterol, triglyceride, low density lipoprotein, whole blood viscosity (high shear, low shear), erythrocyte aggregation index, erythrocyte rigidity index in high dose concentration of Chinese medicine groups and control group were remarkably lower than those in the model group. The statistical result is of great significance(P <0.01).While the difference between high dose concentration of Chinese medicine group and control group was not significant, and there was no statistical significance(P >0.05). Conclusion Qi Huang Ju Yu Fang can treat extremity arteriosclerosis obliterans by improving the disorder of lipid metabolism, reducing blood lipid levels, improving blood rheology.

Key words: Qi Huang Ju Yu Fang, arteriosclerosis occlusive disease, blood lipid, blood rheology, experimental study