Diffusion tensor imaging in brain white matter of AIDS patients with normal appearance on conventional MRI by using tract-based spatial statistics

doi:10.3969/j.issn.1006-7795.2016.04.008

Abstract

Abstract: Objective To analyze the microscopic changes of white matter (WM) in acquired immunodeficiency syndrome (AIDS) patients with normal appearance on conventional magnetic resonance imaging (MRI) by diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Methods Twenty-two acquired immunodeficiency syndrome (AIDS) patients with normal appearance on conventional MRI (patient group) and 23 healthy volunteers (control group) with matched age and sex were recruited. Siemens 3.0T magnetic resonance scanner was used for DTI data acquisition. DTI parameters of WM, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) were compared between the two groups with TBSS. DTI indices with significant difference were further extracted from AIDS patients, correlation analysis was used between DTI indices and CD4⁺ T cell counts. Results Compared with the control group, significantly increased MD were found in several white matter regions including the genu of corpus callosum (GCC), body of corpus callosum (BCC), splenium of corpus callosum (SCC), bilateral anterior corona radiation (ACR), superior corona radiation (SCR), posterior corona radiation (PCR), the left anterior limb of internal capsule (ALIC), external capsule (EC) and cingulate gyrus (CIN-CG) in patient group (P<0.05, corrected by TFEC and FWE); Significantly increased AD were found in the GCC, BCC, SCC, bilateral ACR, SCR, PCR, ALIC, EC and CIN-CG in patient group (P<0.05, corrected by TFEC and FWE). There was more white matter impairment in left hemisphere than that in the right. Corpus callosum and bilateral corona radiata were the larger brain damage regions. The differences of FA values and RD values in every region were not significant between the two groups (P>0.05, corrected by TFEC and FWE). In patient group, significantly negative correlation was found between MD values and CD4⁺ T cell counts in significant clusters (r=-0.457, P=0.034). Conclusion White matter integrity was significantly reduced in extensive regions among AIDS patients with normal appearance on conventional MRI. The pathological features may be the abnormalities in axonal. The involved brain areas mainly related to memory, intelligence and cognitive controls. DTI and TBSS analysis can sensitively discover the white matter microstructure injury in AIDS patients with normal appearance on conventional MRI.

Key words: acquired immunodeficiency syndrome (AIDS), diffusion tensor imaging, white matter, tract-based spatial statistics

CLC Number:

R512.91

Li Ruili, Mi Haifeng, Li Hongjun, Ren Meiji, Zhao Jing, Yuan Da, Wang Wei. Diffusion tensor imaging in brain white matter of AIDS patients with normal appearance on conventional MRI by using tract-based spatial statistics[J]. Journal of Capital Medical University, 2016, 37(4): 454-459.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.04.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I4/454

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