Study on the association between white matter connectivity changes and cognitive deficits in vascular cognitive impairment no dementia using diffusion tensor imaging

doi:10.3969/j.issn.1006-7795.2021.03.006

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (3): 373-384.doi: 10.3969/j.issn.1006-7795.2021.03.006

• Basic and Clinical Research in Neurology Field • Previous Articles Next Articles

Study on the association between white matter connectivity changes and cognitive deficits in vascular cognitive impairment no dementia using diffusion tensor imaging

Qin Qi¹, Tang Yi^1*, Qu Yida², Zhou Aihong¹, Ding Jianping¹, Yin Yunsi¹, Liu Yong^2,3, Jia Jianping^1,4*

1. Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases,Beijing Municipal Geriatric Medical Research Center, Beijing 100053,China;
2. Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190,China;
3. School of Artificial Intelligence, University of Chinese Academy of Sciences; School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing 100876,China;
4. Beijing Key Laboratory of Geriatric Cognitive Disorders; Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University; Center of Alzheimer's Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100053,China

Received:2020-03-17 Online:2021-06-21 Published:2021-06-16
Contact: *E-mail:tangyixw@163.com;jjp@ccmu.edu.cn
Supported by:
National key R&D Program (2016YFC1306305), Capital's Funds for Health Improvement and Research (CFH 2020-4-1033).

Abstract

Abstract: Objective To explore the relationship between vascular cognitive impairment, no dementia (VCIND) and white matter microstructural changes to confirm a diagnosis of dementia. VCIND is the most common subtype of mild cognitive dysfunction. Neuroimaging provides the basis for the early diagnosis, severity and efficacy evaluation of VCIND.However, traditional magnetic resonance imaging (MRI) cannot clarify the relationship between structural changes and cognitive impairment. Methods Diffusion tensor imaging (DTI) was carried out to investigate white matter microstructural changes in 246 brain areas in 31 VCIND patients and 22 normal controls. All patients underwent neuropsychological assessments and DTI examination. Voxel-based analyses were performed to extract fractional anisotropy (FA) and mean diffusivity (MD) measures. Correlation analysis and mediation analysis were performed with cognitive dysfunction. Results Compared with the healthy elderly subjects, subcortical VCIND patients presented with abnormal white matter connectivity changes in several key hubs, especially in frontal lobes. The severity of damage significantly correlated with cognitive dysfunction. FA significantly correlated with general cognitive impairment,memory function and executive function. We also found a significant negative correlation between MD and general cognitive function,memory function and executive function. Mediation analyses demonstrated that the disrupted white matter connectivity could explain the cognitive dysfunction. Conclusions The results indicate that the brain white matter connectivity changes of DTI may be a neuroimaging marker for VCIND early diagnosis and cognitive severity measurement.

Key words: diffusion tensor imaging, vascular cognitive impairment, no dementia, white matter connectivity changes, cognitive function

CLC Number:

R445

Qin Qi, Tang Yi, Qu Yida, Zhou Aihong, Ding Jianping, Yin Yunsi, Liu Yong, Jia Jianping. Study on the association between white matter connectivity changes and cognitive deficits in vascular cognitive impairment no dementia using diffusion tensor imaging[J]. Journal of Capital Medical University, 2021, 42(3): 373-384.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.03.006

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Study on the association between white matter connectivity changes and cognitive deficits in vascular cognitive impairment no dementia using diffusion tensor imaging

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