White matter hyperintensities are related to functional disturbance of upper and lower extremities

doi:10.3969/j.issn.1006-7795.2021.03.007

Abstract

Abstract: Objective To investigate the relationship between white matter hyperintensity(WMH), a common marker of cerebral small vessel disease, and functional disturbance of upper and lower extremities. Methods Totally 256 participants from Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University who underwent magnetic resonance imaging (MRI)were recruited in this cross-sectional study.According to total Fazekas scores they were divided into low WMH burden group(0-2 points) and medium-high WMH burden group(3-6 points). Gait was assessed by 4 metre walkway, Timed Up and Go(TUG)test, Short Physical Performance Battery(SPPB)test and Tinetti test. Upper extremities function was evaluated with 10-repeat pronation-supination time, 10-repeat finger-tapping time and 10-repeat open and close hands time.Univariate and multivariate line regression were used to detect the correlation between function of upper and lower extremities and WMH. Results The mean age of the participants was (61.6±10.1)years. 172(67.2%)were with low WMH burden, while 84(32.8%)with medium-high WMH burden. The multivariable linear regression analyses were performed after adjustments for gender, age, height, vascular risk factors and coexisting markers of cerebral small vessel disease(cSVD).The stride width(β=1.174,P=0.021)and cadence(β=0.533,P=0.022)were correlated with the severity of the WMH, not step length and velocity (β=-1.550,P=0.228;β=0.062,P=0.429). We also found that the participants had lower Tinetti and SPPB score(β=-1.127,P=0.000;β=-0.844,P=0.000)and needed more time to achieve TUG (β=1.518,P=0.000) in medium-high WMH burden group.There were significant differences in 10-repeat pronation-supination time, 10-repeat finger-tapping time and 10-repeat open and close hands time between medium-high WMH burdenand low WMH burden (β=0.635,P=0.021;β=0.962,P=0.000;β=0.518,P=0.020). Conclusions Our study suggested that gait disturbances and upper extremities disorders were related with medium-high WMH burden. It may be helpful to explore the mechanism ofmovement disorder resulting from WMH.

Key words: movement disorder, white matter hyperintensities, upper extrenities, gait

CLC Number:

R741

Hou Yutong, Yang Shuna, Li Yue, Li Xuanting, Hu Wenli. White matter hyperintensities are related to functional disturbance of upper and lower extremities[J]. Journal of Capital Medical University, 2021, 42(3): 385-390.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.03.007

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I3/385

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