Cognitive impairment in patients with depersonalization disorder and its correlation with clinical symptoms and social function

doi:10.3969/j.issn.1006-7795.2020.01.012

Abstract

Abstract: Objective To study the impairment of cognitive function in patients with depersonalization disorder and its correlation with clinical symptoms and social function. Methods Forty eight who meet the diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition, DSM-V) and the Cambridge Depersonalization Scale (CDS) score of ≥ 70 patients with personality disintegration disorder and 32 healthy subjects used Trail Making Test A (TMTA), symbolic coding, Hopkins Verbal Learning Test Revised (HVLT-R), Brief Visuospatial Memory Test Revised (BVMT-R), Continuous Performance Test (CPT) and Stroop Color Test for cognitive function assessment, and collect general demographic and clinical information on relevant information perform analysis. Results There were significant differences in cognitive function of TMTA (P=0.03), HVLT-R (P=0.01), BVMT-R (P=0.01), and Stroop test (P=0.01) between the depersonalized patients and the healthy controls; There was no statistically significant difference in cognitive function between the medication group and the non-medication group in patients with disintegrated personality (P>0.05). There was a statistically significant difference in Global Assessment Function(GAF) scores on social function between the depersonalized patient group and the healthy test group (P=0.00); Stroop test and CPT test in cognitive function were negatively correlated with clinical symptoms (r=-0.455, P<0.05; r=-0.292, P<0.05), and TMAT test was negatively correlated with social function (r=-0.300, P<0.05), the Stroop test and the BVMT-R test were positively correlated with social function (r=0.352, P<0.05; r=0.344, P<0.05), but the relationship was weak. Conclusion Patients with personality disintegration have cognitive impairment and social function decline. Attention/alertness in cognitive function is negatively correlated with clinical symptom scores. There is a correlation between cognitive function and social function. Impaired cognitive function can lead to social function decline.

Key words: depersonalization disorder, cognitive function, Cambridge Depersonalization Scale, social function, relevance

CLC Number:

R149.91

Song Nan, Jia Hongxiao. Cognitive impairment in patients with depersonalization disorder and its correlation with clinical symptoms and social function[J]. Journal of Capital Medical University, 2020, 41(1): 59-63.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.01.012

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I1/59

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