Comparison on the early efficacy and cognitive effect of magnetic seizure therapy and modified electroconvulsive therapy for depressive episodes

doi:10.3969/j.issn.1006-7795.2022.02.013

Abstract

Abstract: Objective To compare the early efficacy and effect on cognitive function of magnetic seizure therapy (MST) and modified electroconvulsive therapy (MECT) in the treatment of depressive episode. Methods A total of 45 patients with depression were treated with MST or MECT respectively. Hamilton Depression Scale-17 Item (HAMD-17), Hamilton Anxiety Scale (HAMA), and Clinical Global Impression Scale (CGI) was used to evaluate clinical symptoms. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Mini-mental State Examination (MMSE) were used to evaluate cognitive function. The evaluation time points included baseline, after 3 times and 6 times of treatment. Results Repeated measurement ANOVA showed that there was no significant difference in HAMD-17, HAMA, CGI-S and CGI-I scores between the two groups before and after treatment (P_group>0.05). HAMD-17, HAMA and CGI-S scores decreased along with the extension of treatment time (P_time<0.05). The total score of RBANS in both groups increased gradually with the extension of treatment time (P_time<0.05). At each time point, the total score of RBANS in MST group was higher than that in MECT group, with statistically significant difference between the groups (P_group<0.05), and the therapeutic effect of MST increased with time (P_time<0.05). After 3 and 6 times of treatment, there was no significant difference in HAMD score reduction rate between the two groups. Conclusion The early efficacy of MST was comparable to MECT in the treatment of depressive episode. MST improved the cognitive function of patients after 6 treatment times.

Key words: magnetic seizure therapy, modified electroconvulsive therapy, depressive episode, early efficacy, cognitive function

CLC Number:

R749.4

Ren Yanping, Zhang Junyan, Wu Han, Luo Jiong, Yang Chunlin, Ma Xin, Jiang Wei. Comparison on the early efficacy and cognitive effect of magnetic seizure therapy and modified electroconvulsive therapy for depressive episodes[J]. Journal of Capital Medical University, 2022, 43(2): 239-243.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.02.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I2/239

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