Efficacy and safety of transcranial alternating-current stimulation combined with antidepressants in the treatment of depressive episode

doi:10.3969/j.issn.1006-7795.2022.02.014

Journal of Capital Medical University ›› 2022, Vol. 43 ›› Issue (2): 244-248.doi: 10.3969/j.issn.1006-7795.2022.02.014

• Research of Neurostimulation Treatment and Rehabilitation for Mental Disease • Previous Articles Next Articles

Efficacy and safety of transcranial alternating-current stimulation combined with antidepressants in the treatment of depressive episode

Luo Jiong^1,2, Sun Congcong^1,2, Pan Weigang^1,2, Wang Dan^1,2, Shi Xiaoning^1,2, Wang Qian^1,2, Jin Wenqing^1,2, Liang Lirong³, Yang Chunlin^1,2, Ma Xin^1,2, Ren Yanping^1,2*

1. Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing Key Laboratory of Mental Disorders & The National Clinical Research Center for Mental Disorders, Beijing 100088, China;
2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069,China;
3. Department of Clinical Epidemiology, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

Received:2021-11-10 Online:2022-04-21 Published:2022-04-14
Contact: *E-mail:renyanping@ccmu.edu.cn
Supported by:
Beijing Municipal Science & Technology Commission (D171100007017001).

Abstract

Abstract: Objective To investigate the efficacy and safety of transcranial alternating current stimulation (tACS) combined with antidepressants in the treatment of depression. Methods Sixty-two patients with depressive episode were randomly divided into treatment group and control group. Both groups took antidepressants. The patients in the treatment group received real tACS while the patients in the control group were treated with sham tACS. The treatment session was 20 times in both groups. The treatment site was prefrontal and bilateral mastoid, with a frequency of 77.5 Hz and intensity of 15 mA. Hamilton Depression Scale-17 Item (HAMD-17) and Hamilton Anxiety Scale (HAMA) were used to evaluate the clinical symptoms at baseline, the end of treatment (4 weeks), and follow-up (8 weeks). Results The scores of HAMD-17 and HAMA in the treatment and control groups at baseline, 4 weeks of treatment, and 8 weeks of follow-up were compared with repeated measurement analysis of variance. The total score of HAMD-17 in the two groups decreased gradually with the extension of treatment and follow-up time (P _time<0.05). The decrease in the treatment group was greater than that in the control group (P _group<0.05), and the effect of treatment increased with the extension of observation time (P_interaction<0.05). The total score of HAMA in both groups decreased gradually with the extension of treatment and follow-up time (P _time<0.05). However, there was no significant difference between the two groups (P _group>0.05). The score reduction rates of HAMD-17 in the treatment and control groups at the end of the fourth week were74.29%±8.40% vs 32.54%±13.30%, respectively. At the end of the 8th week, the score reduction rates of HAMD-17 were 81.00%±10.68% vs 40.27%±12.92%, respectively. The difference was statistically significant (P<0.001). Conclusion tACS combined with antidepressants is effective and safe in the treatment of depressive episodes. It can be used as a new choice for the combined treatment of depressive episodes.

Key words: transcranial alternating-current stimulation (tACS), depressive episode, efficacy, safety

CLC Number:

R749.4

Luo Jiong, Sun Congcong, Pan Weigang, Wang Dan, Shi Xiaoning, Wang Qian, Jin Wenqing, Liang Lirong, Yang Chunlin, Ma Xin, Ren Yanping. Efficacy and safety of transcranial alternating-current stimulation combined with antidepressants in the treatment of depressive episode[J]. Journal of Capital Medical University, 2022, 43(2): 244-248.

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References

[1] 马辛, 李淑然, 向应强, 等. 北京市抑郁症的患病率调查[J]. 中华精神科杂志, 2007, 40(2): 100-103.
[2] WHO. Depression and other common mental disorders: global health estimates[R]. Geneva: World Health Organization, 2017: 1-24.
[3] Smith K. Mental health: a world of depression[J]. Nature, 2014, 515(7526): 181.
[4] Fava M. Diagnosis and definition of treatment-resistant depression[J]. Biol Psychiatry, 2003, 53(8): 649-659.
[5] Antal A, Paulus W. Transcranial alternating current stimulation (tACS)[J]. Front Hum Neurosci, 2013, 7: 317.
[6] 王红星, 王坤, 孙志超, 等. 经颅交流电刺激干预从未药物治疗的抑郁症患者的疗效初探[J]. 中华医学杂志, 2020, 100(3): 197-201.
[7] Wilkening A, Kurzeck A, Dechantsreiter E, et al. Transcranial alternating current stimulation for the treatment of major depression during pregnancy[J]. Psychiatry Res, 2019, 279: 399-400.
[8] Haller N, Senner F, Brunoni A R, et al. Gamma transcranial alternating current stimulation improves mood and cognition in patients with major depression[J]. J Psychiatr Res, 2020, 130: 31-34.
[9] American Psychiatric Association. Diagnostic and statistical manual for mental disorders[M]. 5th ed. Washington DC: American Psychiatric Association,2013.
[10] Bergfeld I O, Mantione M, Figee M, et al. Treatment-resistant depression and suicidality[J]. J Affect Disord, 2018, 235: 362-367.
[11] Lebedev V P, Malygin A V, Kovalevski A V, et al. Devices for noninvasive transcranial electrostimulation of the brain endorphinergic system: application for improvement of human psycho-physiological status[J]. Artif Organs, 2002, 26(3): 248-251.
[12] Ai∨rapetov L N, Zai∨chik A M, Trukhmanov M S, et al. Changes in the beta-endorphin levels in the brain and cerebrospinal fluid during transcranial electroanalgesia[J]. Fiziol Zh SSSR Im I M Sechenova, 1985, 71(1): 56-64.
[13] Lande R G, Gragnani C. Efficacy of cranial electric stimulation for the treatment of insomnia: a randomized pilot study[J]. Complement Ther Med, 2013, 21(1): 8-13.
[14] Matsumoto H, Ugawa Y. Adverse events of tDCS and tACS: a review[J]. Clin Neurophysiol Pract, 2017, 2: 19-25.
[15] Fertonani A, Ferrari C, Miniussi C. What do you feel if I apply transcranial electric stimulation? Safety, sensations and secondary induced effects[J]. Clin Neurophysiol, 2015, 126(11): 2181-2188.

Efficacy and safety of transcranial alternating-current stimulation combined with antidepressants in the treatment of depressive episode

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