Journal of Capital Medical University ›› 2022, Vol. 43 ›› Issue (2): 249-253.doi: 10.3969/j.issn.1006-7795.2022.02.015

• Research of Neurostimulation Treatment and Rehabilitation for Mental Disease • Previous Articles     Next Articles

Research advances of modified electroconvulsive therapy for first-episode schizophrenia

Li li1,2, Liu Chaomeng1,2, Ren Yanping1,2, Yang Chunlin1,2, Ma Xin1,2*   

  1. 1. Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing Key Laboratory of Mental Disorders & The National Clinical Research Center for Mental Disorders, Beijing 100088, China;
    2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069,China
  • Received:2021-11-10 Online:2022-04-21 Published:2022-04-14
  • Contact: *E-mail:maxinanding@ccmu.edu.cn
  • Supported by:
    Capital's Funds for Health Improvement and Research(2018-3-1171), Beijing Municipal Science & Technology Commission (D171100007017001).

Abstract: As one of the commonly used physical therapy methods in clinical practice, modified electroconvulsive therapy (MECT) is currently recommended for patients with acute exacerbations of positive symptoms or catatonia. First-episode schizophrenia (FES) usually begins in adolescence or early adulthood, and the prognosis of FES is crucial to the shaping of the patient's personality and the maintenance of social relationships in the later period. Starting from the mechanism of action, this paper summarized the research progresses in the MECT for FES and found that MECT not only takes effect quickly but also shows long-term therapeutic effect in the maintenance period, with good safety. However, there are not enough studies on MECT treatment for FES at present, and the overall quality of the included studies is plain. The reliability of the conclusions needs to be confirmed by multi-center and large sample randomized controlled studies.

Key words: modified electroconvulsive therapy, first-episode schizophrenia, efficacy, safety, mechanism

CLC Number: