Journal of Capital Medical University ›› 2020, Vol. 41 ›› Issue (1): 55-58.doi: 10.3969/j.issn.1006-7795.2020.01.011

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Clinical changes of cognitive function patients with spleen deficiency

Wu Fengzhi1, Ning Yanzhe2,3, Jia Hongxiao2,3   

  1. 1. Beijing University of Chinese Medicine, Beijing 100029, China;
    2. The National Clinical Research Center, Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;
    3. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China
  • Received:2019-12-02 Online:2020-02-21 Published:2020-02-13
  • Supported by:
    This study was supported by National Natural Science Foundation of China (81873398,81904120),Capital Health Research and Development of Special Funding (2018-1-2122),Chinese Medicine Science and Technology Development Fund of Beijing (QN 2018-27), Beijing Hospitals Authority' Ascent Plan(DFL20191901).

Abstract: Objective To study the clinical characteristics of cognitive function change in patients with spleen deficiency(PSD). Methods Twenty six subjects with spleen deficiency syndrome and 25 healthy subjects were measured by Clinical Memory Scale Test(CMS) and Continue Performance Test(CPT), which were used to assess memory and attention. Results Compared with healthy controls, patients with spleen deficiency syndrome showed significantly lowered scores in the directed memory(t=-3.60, P=0.001), associative memory(z=-3.47, P=0.001)and meaningless image recognition(t=-2.09, P=0.037), but high in the scores of 2-FT(Z=3.13, P=0.002)and 3-FT(Z=2.45, P=0.014). Conclusion Our findings suggest that patients with spleen deficiency syndrome showed impaired memory and attention, which provide new evidence to support treating cognitive disorder from spleen.

Key words: spleen deficiency syndrome, cognitive function, memory, attention

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