Correlation between serum vitamin A and vitamin E and cognitive function in aging subjects with type 2 diabetes mellitus

doi:10.3969/j.issn.1006-7795.2023.06.023

Abstract

Abstract: Objective To investigate the correlation between serum vitamin A and vitamin E levels and cognitive function in aging subjects in older adults with type 2 diabetes mellitus (T2DM). Methods A total of 500 T2DM patients were recruited from Communities. And 500 age, gender and education level matched non-diabetic healthy adults were recruited as normal control subjects. A self-designed questionnaire was used to investigate socio-demography, lifestyle, disease history and other factors. Montreal Cognitive Assessment (MoCA) scale was used to assess the cognitive function. Fasting venous blood was collected for biochemical parameters including fasting blood glucose (FBG), total blood cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) levels. The serum levels of vitamin A (VA) and vitamin E (VE) were detected by high performance liquid chromatography (HPLC). SPSS 20.0 was used to statistically analyze the data. ResultsAmong the T2DM group, the serum VA level of those with normal cognitive function (0.59 μg/mL) was higher than that of those with mild cognitive impairment (MCI) (0.50 μg/mL), and the difference was statistically significant (P<0.01). The serum VE level of those with normal cognitive function (12.22 μg/mL) were higher than those with MCI (11.40 μg/mL), but the difference was no statistically significance (P>0.05). Serum VA levels in T2DM group were positively correlated with the total MoCA score and all scores (except the orienting function); and higher concentrations of serum VA levels were associated with a reduced risk of developing diabetes compared with lower levels (OR<1, P<0.05). Conclusion In this study, we found that higher serum VA levels were associated with better cognitive function. Thus, higher serum VA levels may act as a protective factor for cognitive function in elderly with T2DM. However, there is no association between serum VE level and cognitive function in the elderly.

Key words: diabetes, vitamin A, vitamin E, cognitive function

CLC Number:

Gao Yanyan, Ren Xiuwen, Wang Xixiang, Xu Jingjing, Ma Xiaojun, Liu Lu, Liu Yu, Yuan Linhong. Correlation between serum vitamin A and vitamin E and cognitive function in aging subjects with type 2 diabetes mellitus[J]. Journal of Capital Medical University, 2023, 44(6): 1060-1066.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.06.023

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I6/1060

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