Journal of Capital Medical University ›› 2020, Vol. 41 ›› Issue (1): 50-54.doi: 10.3969/j.issn.1006-7795.2020.01.010

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Current status of research concerning animal models of cognitive impairment of schizophrenia

Liu Xinyao1,2, Ma Chao1,2, Jia Hongxiao1,2   

  1. 1. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;
    2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China
  • Received:2019-12-02 Online:2020-02-21 Published:2020-02-13
  • Supported by:
    This study was supported by National Natural Science Foundation of China (81873398, 81904120),Capital Health Research and Development of Special Founding(2018-1-2122), Chinese Medicine Science and Technology Development Found of Beijing (QN2018-27), Beijing Hospitals Authority's Ascent Plan(DFL20191901).

Abstract: The mechanism of schizophrenia is not yet precise. Cognitive impairment is a difficult point in the treatment of schizophrenia. Reliable and predictable animal models could improve understanding of the neurobiological basis of the disease, and also is crucial for developing new drugs that work better. This review will focus on pharmacological models, neurodevelopmental models and genetic models and provides ideas for studying and alleviating the cognitive impairment of schizophrenia.

Key words: schizophrenia, animal model, cognition

CLC Number: