Analysis of influencing factors of time prolongation of time up and go test in maintenance hemodialysis patients

doi:10.3969/j.issn.1006-7795.2025.01.020

Abstract

Abstract: Objective To explore the influence factors of timed up and go test (TUG) in patients with maintenance hemodialysis (MHD). Methods Cross-sectional investigation method was used to select patients who underwent regular hemodialysis in Beijing Luhe Hospital, Capital Medical University from June 1, 2023 to January 31, 2024, with complete data and cooperation. The patients were respectively treated with a simple mental state checklist and 5 times sit to stand test (STS-5) and TUG scale were used to assess cognitive function, lower limb muscle strength, balance and gait function. Grouping was carried out according to the results of TUG. If TUG ≤ 12s, it is judged as the TUG normal group; if TUG > 12s, it is judged as the TUG prolonged group. Multi-factor Logistic regression was used to analyze the influencing factors in the TUG prolonged group, and the predictive value of influencing factors to TUG prolonged patients was analyzed by receiver operating characteristic (ROC) curve. Results A total of 146 patients with MHD were included in this study, including 86 patients in TUG prolonged group and 60 patients in TUG normal group. Gender, age, combined hypertension, combined diabetes, blood glucose, education level, Minimum Mental State Examination (MMSE) score, C-reactive protein were compared between groups. Serum albumin, serum creatinine, serum sodium, whole parathyroid hormone, low density lipoprotein-cholesterol, serum uric acid, STS-5 results, and single urea clearance index（Kt/V） had statistical differences (P<0.05). Multivariate Logistic regression showed that old age, female, low MMSE score, low Kt/V, and STS-5 duration were independent risk factors for TUG prolonged (P<0.05). ROC curve showed that the area under the curve （AUC）of age, gender, total MMSE score and STS-5 time in predicting TUG prolongation in MHD patients were 0.825, 0.678, 0.777 and 0.836, respectively (P<0.01), which had high predictive value. The AUC of Kt/V in predicting TUG prolongation was 0.602 (P=0.037), has a certain predictive value;AUC of TUG prolongation in MHD patients predicted by the above 5 indicators as a global model was 0.923 (P<0.01).Conclusions The age, gender, MMSE score, STS-5 prolongation and Kt/V level of MHD patients are independent risk factors for TUG prolongation, and may be biological indicators for predicting TUG prolongation.

Key words: maintenance hemodialysis, timed up and go test(TUG), cognition, cross-sectional study

CLC Number:

R692.5

Zhang Xiao, Zhang Wei, Wang Zunli, Wen Nuan, Liu Conghui, Li Zhongxin. Analysis of influencing factors of time prolongation of time up and go test in maintenance hemodialysis patients[J]. Journal of Capital Medical University, 2025, 46(1): 130-135.

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