Abstract: Objective  To investigate on the change of cognitive function and social function in subhealthy people with spleen qi deficiency syndrome (SQDS). Methods  Totally 24 subhealthy people with SQDS and 27 healthy people matched for age, gender, and education time were evaluated with Repeatable Battery for the Assessment of Neuropsychological Status(RBANS), Global Assessment of Functioning Scale(GAF) and Symptom of SQDS Scale. Results  Compared with healthy controls, subhealthy people with SQDS showed significantly decreased scores in visuospatial index, attention index, delayed memory index, total scale and GAF(P<0.05), while scores differences in immediate memory index and language index were not statistically significant(P>0.05). Moreover, delayed memory index score(r=－0.532，P=0.009) and total scale score(r=－0.474，P=0.022)  were negatively correlated with syndrome of SQDS scale score, but delayed memory index score(r=0.564，P= 0.004) and total scale score(r = 0.785，P<0.001) were positively correlated with GAF score. Conclusions  The impairment of visuospatial ability, attention, memory and social function was observed in subhealthy people with SQDS, and poor memory was significantly associated with symptom of SQDS  and social function. It provided experimental evidence for the treatment of dysfunctional cognition diseases from the viewpoint of traditional Chinese medicine theory of spleen and enriched the connotation of spleen stores yi.

Key words: spleen qi deficiency syndrome, subhealth, cognition function, social function, spleen stores yi