Sensitization patterns for aeroallergens in self-reported allergic rhinitis within Beijing, Tianjin, and Hebei region

doi:10.3969/j.issn.1006-7795.2017.05.008

Abstract

Abstract: Objective The aim was to assess the patterns of aeroallergen sensitizations in patients with self-reported allergic rhinitis (AR), analyze the differences of aeroallergen sensitization rates in different age groups and genders, and demonstrate the clinical relevance of positive aeroallergen with AR symptoms and allergic comorbidities. Methods A total of 6 236 patients suffering from AR symptoms in Beijing, Tianjin and Hebei region underwent standardized skin prick test (SPT) with 20 common aeroallergens during the period from January 2011 to July 2013 when seeking medical help in Beijing Tongren Hospital. Nasal symptom visual analogue score and the history of asthma and allergic conjunctivitis were recorded. Chi-square and Spearman correlation tests were used in statistical analysis. Results Among the 6 236 self-reported AR patients investigated, 5 530 (88.7%) had at least one positive skin prick reaction. The most common aeroallergen in this area were house dust mites (HDMs), with the sensitization rates (SRs) as 47.3% for Der f and 41.7% for Der p, respectively. SRs of HDMs decreased with age and were higher in males compared to females. Higher SRs of outdoor aeroallergens were observed in moderate-severe AR and persistent AR, whereas HDM SRs were not different between AR classifications. Skin index (SI) of HDMs was not relevant to AR symptoms, but SIs of mugwort and grass pollen were positively correlated with the severity of AR symptoms. More than 4 positive allergens were found in over 54% of patients with AR and comorbidities. HDMs and Blatella were not associated with AR and allergic comorbidities, whereas SRs of outdoor allergens (mugwort, dandelion and ragweed) were significantly higher in patients with AR and comorbidities compared to only AR patients. Conclusion Dust mites were the most prevalent allergens in patients with AR in Beijing, Tianjin and Hebei region. Sensitization pattern of aeroallergens varied with age and genders. Higher SRs and multiple sensitizations were associated with AR comorbidities. SRs of outdoor allergens were positively correlated with severity of AR.

Key words: allergic rhinitis, aeroallergen, sensitization, comorbidities, clinical relevance

CLC Number:

R765.21

Lou Hongfei, Ma Siyuan, Zhao Yan, Cao Feifei, He Fei, Wang Xiangdong, Wang Chengshuo, Zhang Luo. Sensitization patterns for aeroallergens in self-reported allergic rhinitis within Beijing, Tianjin, and Hebei region[J]. Journal of Capital Medical University, 2017, 38(5): 665-670.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.05.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I5/665

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