A multi-center prospective case series study on the treatment of allergic rhinitis by acupuncture of sphenopalatine ganglion

doi:10.3969/j.issn.1006-7795.2019.06.019

Journal of Capital Medical University ›› 2019, Vol. 40 ›› Issue (6): 916-920.doi: 10.3969/j.issn.1006-7795.2019.06.019

A multi-center prospective case series study on the treatment of allergic rhinitis by acupuncture of sphenopalatine ganglion

Zhang Peng¹, Yang Wei¹, Wang Kuiji¹, Tan Yi¹, Shang Xiaojuan¹, Shu Ning², Wang Xiang³, Xu Shiwen⁴, Sun Sanfeng⁵, Zhao Xinyu⁶, Yu Kun⁷, Chen Luquan¹

1. Department of Acupuncture-Moxibustion, Beijing Tongren Hospital, Capital Medical University, Beijing 100010, China;
2. Department of Acupuncture-Moxibustion, Beijing Hui'an Integrated Hospital of Traditional Chinese and Western Medicine, Beijing 100071, China;
3. Department of Acupuncture-Moxibustion, Beijing Tongzhou District Integrated Hospital of Traditional Chinese and Western Medicine, Beijing 101149, China;
4. Department of Acupuncture-Moxibustion, Beijing Pinggu District Hospital of Traditional Chinese Medicine, Beijing 101200, China;
5. Department of Acupuncture-Moxibustion, Beijing Huairou District Hospital of Traditional Chinese Medicine, Beijing 101400, China;
6. Department of Acupuncture-Moxibustion, Beijing Chaoyang District Hospital of Traditional Chinese Medicine, Beijing 100020, China;
7. Yuetan Community Health Service Center, Fuxing Hospital, Capital Medical University, Beijing 100032, China

Received:2019-03-25 Online:2019-11-21 Published:2019-12-18
Supported by:
This study was supported by Beijing Talents of Youth Backbone(2014000021469G263),The Open Project of Beijing Key Laboratory of Management Research(2014BBYJ01).

Abstract

Abstract: Objective To evaluate the clinical efficacy of acupuncture on sphenopalatine ganglion in the treatment of allergic rhinitis (AR). Methods Totally 222 patients with allergic rhinitis were enrolled in 7 sub-centers from April 2017 to June 2018. The baseline of the patients was the same among the sub-centers, once a week for 4 times. Total nasal symptom score (TNSS) and total nonnasal symptom score (TNNSS) were evaluated before treatment, 2, 3, 4 and 8 weeks, respectively. Rhinconjunctivitis quality of life questionnaire (RQLQ) was evaluated before treatment, 4 and 8 weeks. Results One of 222 patients was lost to follow-up. Totally 221 TNSS, 218 TNNSS and 213 RQLQ were included in the effective scale. The scores of patients' TNSS scale and TNNSS scale decreased continuously from the 2^nd week of acupuncture to the 8^th week (4 weeks after the end of treatment, the end point of observation). The scores of RQLQ scale decreased significantly at the 4^th week and continued to decrease to the 8^th week. The differences were statistically significant. One patient had mild adverse reaction of cheek swelling. During the 8-week observation period, the control rate of AR patients exceeded 80%. Conclusion Acupuncture of sphenopalatine ganglion is effective, safe and can be popularized in the treatment of AR. Further research will increase objective index evaluation, supplement observation of immediate effect of acupuncture, refine the types of possible adverse reactions, prolong the follow-up time, clarify the effect of different stimulation methods on AR treatment effect, standardize the acupuncture program, and optimize the patient's treatment experience.

Key words: sphenopalatine ganglion, acupuncture therapy, allergic rhinitis, case series study, integrated traditional Chinese and Western Medicine

CLC Number:

R765.21

Zhang Peng, Yang Wei, Wang Kuiji, Tan Yi, Shang Xiaojuan, Shu Ning, Wang Xiang, Xu Shiwen, Sun Sanfeng, Zhao Xinyu, Yu Kun, Chen Luquan. A multi-center prospective case series study on the treatment of allergic rhinitis by acupuncture of sphenopalatine ganglion[J]. Journal of Capital Medical University, 2019, 40(6): 916-920.

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References

[1] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南(2015年,天津)[J].中华耳鼻咽喉头颈外科杂志,2016,51(1):6-24.
[2] 李新吾.针刺蝶腭神经节——"治鼻3"穴位治疗鼻部疾病的机制分析及有关针刺方法的介绍[J].临床耳鼻咽喉头颈外科杂志,2011,25(5):193-196.
[3] 张路,杨威,王克键.针刺蝶腭神经节治疗慢性单纯性鼻炎71例[J].中国针灸,2013,33(6):495-496.
[4] 张燕超. 针刺治疗过敏性鼻炎的临床疗效观察[D].北京:北京中医药大学,2013.
[5] 陈陆泉,杨宇洋,杨威.通过蝶腭神经节治疗变应性鼻炎的临床研究进展[J].北京中医药,2012,31(8):631-633.
[6] 李新吾,田平忠.治疗鼻炎新法"针刺蝶腭神经节"的初步总结[J].北京中医,1990(4):36-38.
[7] Undem B J,Taylor-Clark T. Mechanisms underlying the neuronal-based symptoms of allergy[J].J Allergy ClinImmunol,2014,133(6):1521-1534.
[8] Zhao C, Ji Y, An Y, Xue J, et al. An alternative method of endoscopic intrasphenoidal vidian neurectomy[J].OTO Open, 2018,2(1):2473974X1876-4862.
[9] Ikeda K, Yokoi H, Saito T, et al. Effect of resection of theposterior nasal nerve on functional and morphological changes in the inferior turbinate mucosa[J].Acta Otolaryngol,2008,128(12):1337-1341.
[10] 王奎吉,陈陆泉,王阳,等.针刺蝶腭神经节对正常人鼻腔神经功能的影响[J].中国耳鼻咽喉头颈外科,2016,23(8):483-486.
[11] 王奎吉,陈陆泉,王阳,等.针刺蝶腭神经节对正常青年人鼻腔通气功能影响的研究[J].临床军医杂志,2016,44(8):801-804.
[12] 许庆庆,段甦,王向东,等.鼻中隔偏曲矫正对变应性鼻炎患者治疗效果的Meta分析[J].首都医科大学学报,2018,39(6):928-932.
[13] 袁媛,姜长青,陈玥,等.神经调控技术的发展与展望[J].生命科学仪器,2018,16(Z1):20-28,70.
[14] 王奎吉,陈陆泉,王阳. 针刺蝶腭神经节对正常青年人鼻腔通气功能影响的研究[J].临床军医杂志,2016,44(8):801-804.
[15] Wang K, Chen L, Wang Y, et al. Sphenopalatine ganglion acupuncture improves nasal ventilation and modulates autonomic nervous activity in healthy volunteers:a randomized controlled study[J]. Sci Rep,2016,6:29947.
[16] Chen L, Chen J, Fu Q, et al. Chinese Society of Allergy Guidelines for diagnosis and treatment of allergic rhinitis[J]. Allergy, Asthma Immunol Res,2018,10(4):300-353.

A multi-center prospective case series study on the treatment of allergic rhinitis by acupuncture of sphenopalatine ganglion

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