Research progress of NADPH oxidase in inflammatory diseases of respiratory tract

doi:10.3969/j.issn.1006-7795.2018.01.013

Abstract

Abstract: Nico-tinamide adenine dinucleotide phosphate (NADPH) oxidase was first found in the respiratory burst of phagocytic cells. It was also found that NADPH oxidase was expressed in epithelial cells, endothelial cells and other non-phagocytic cells. NADPH oxidase is closely related with reactive oxygen species (ROS) production, intracellular redox reaction,oxidative stress and signal transduction. It also has certain correlation with the occurrence and development of manychronic diseases, such as cardiovascular diseases, respiratory diseases and so on. This article briefly reviews the research progress of NADPH oxidase in inflammatory diseases of respiratory tract.

Key words: nico-tinamide adenine dinucleotide phosphate (NADPH) oxidase, reactive oxygen species (ROS), oxidative stress, allergic rhinitis (AR), chronic rhinosinusitis (CRS), asthma, chronic obstructive pulmonary disease (COPD)

CLC Number:

R765

Zheng Kaili, Wang Xiangdong, Zhang Luo. Research progress of NADPH oxidase in inflammatory diseases of respiratory tract[J]. Journal of Capital Medical University, 2018, 39(1): 69-73.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.01.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I1/69

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