Abstract: Objective To explore the effects of vitamin D₂ soft capsules and calcitriol soft capsules on albuminuria in type 2 diabetes mellitus(T2DM) patients with diabetic kidney disease(DKD). Methods Totally 95 T2DM patients with DKD and estimated glomerular filtration rate (eGFR)≥60 mL·(min·1.73 m2)^-1 who hospitalized in the department of endocrinology  of a tertiary hospital in Beijing from October 2020 to March 2022 were analyzed retrospectively. According to the treatment protocols, the patients were divided into control group without vitamin D preparation (CON group, n=33), natural vitamin D group with vitamin D2 soft capsule (NVD group, n=31), and active vitamin D group with calcitriol soft capsule (AVD group, n=31). The clinical data and parameters of vitamin D and DKD, including serum 25-hydroxyvitamin D (25OHD), serum parathyroid hormone (PTH), blood calcium, urine calcium and urinary albumin-to-creatinine ratio (UACR) at baseline and after 12 weeks treatment were collected through the electronic medical records database system. Results In the baseline phase, there were 8 cases (24.24% ), 9 cases (29.03% ), and 7 cases (22.58% ) with macroalbuminuria in CON group, NVD group, and AVD group, respectively, with no significant difference（P=0.831）。After 12 weeks of treatment, the level of ln(UACR) decreased significantly（both P<0.001）, with no significant difference between the two treatment groups（P=0.371）. The total effective rates of NVD group and AVD group were 80.65%  and 74.19%  respectively, which were significantly higher than those of CON group（33.33% ）（P<0.001 and P=0.002）. There was no significant difference between NVD group and AVD group（P=0.245）. There were 1 case of blood calcium increased, 1 case of hypercalciuria, 1 case of hyperuricemia, 1 case of kidney stone, and 1 case of muscle spasm in CON group, 1 case of hypercalciuria and 1 case of hyperuricemia in NVD group, 1 case of blood calcium increased, 1 case of hypercalcaemia, 1 case of blood parathyroid hormone decreased, 2 cases of hypercalciuria, and 2 cases of hyperuricemia in AVD group. No drug withdrawal occurred in both treatment groups. Conclusion The administration of both Vitamin D₂ soft capsule and calcitriol soft capsule can effectively reduce albuminuria levels in T2DM patients with DKD with good renal function and significantly. Natural vitamin D may be safer compared with active vitamin D.

Key words: type 2 diabetes mellitus, vitamin D₂, calcitriol, diabetic kidney disease, albuminuria