The causal relationship between intestinal flora and diabetes, inflammatory factors and C-reactive protein: Mendelian randomized analysis

doi:10.3969/j.issn.1006-7795.2024.03.017

Abstract

Abstract: Objective To explore the relationship between intestinal flora and diabetes mellitus, inflammatory factors and C-reactive protein (CRP).Methods In this study, the intestinal flora was taken as exposure factors while diabetes, inflammatory factors and CRP were taken as outcome factors, and single nucleotide polymorphisms（SNPs） were used as instrument variables. Mendelian randomization method was used. Results Coprococcus1, Dialister, Lachnospiraceae and Parabacteroides were less abundant in the diabetes population whereas Bilophila and Romboutsia were more abundant in the diabetes population. Dialister is positively correlated with interleukin-17（IL-17） (β=0.797, P=0.036). CRP is negatively correlated with Coprococcus1 (β＝－0.036, P=0.027), Parabacteroides (β＝－0.216, P=0.015), and Dialister (β＝－0.028, P=0.030). CRP showed the mediation effect in the relationship between two bacteria (Coprococcus1 and Parabacteroides) and diabetes.Conclusion Our study suggests the potential interactions between intestinal flora, CRP and diabetes.

Key words: intestinal flora mellitus, diabetes mellitus, inflammatory factors, C-reactive protein, Mendelian randomization

CLC Number:

R587.1

Hu Yafen, Hua Lin. The causal relationship between intestinal flora and diabetes, inflammatory factors and C-reactive protein: Mendelian randomized analysis[J]. Journal of Capital Medical University, 2024, 45(3): 488-493.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2024.03.017

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2024/V45/I3/488

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