Research progress of cathepsin in the mechanism of diabetes and diabetic nephropathy

doi:10.3969/j.issn.1006-7795.2023.03.009

Abstract

Abstract: Cathepsin is one of the most important proteolytic enzymes in mammals, which exists both intracellularly and extracellularly. It participates in various physiological and pathological processes in vivo such as regulating autophagy, cell apoptosis, maintaining extracellular matrix homeostasis, antigen presentation, viral infection and inflammation. In recent years, cathepsin B (CTSB), cathepsin D (CTSD), cathepsin L (CTSL), and cathepsin S (CTSS) have been considered to be the main players in metabolic diseases. They are involved in the pathogenesis and progression of mellitus (DM） and diabetic nephropathy (DN) and may become potential new targets for prediction and treatment. This article reviews the role and mechanism of CTSB, CTSD, CTSL, and CTSS in DM and DN.

Key words: cathepsin, diabetes mellitus, diabetic nephropathy, research progress

CLC Number:

Li Mingjia, Zhao Miaomiao , Yang Jinkui . Research progress of cathepsin in the mechanism of diabetes and diabetic nephropathy[J]. Journal of Capital Medical University, 2023, 44(3): 413-419.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.03.009

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I3/413

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