关键词: 老年人, 踝臂指数, 尿白蛋白肌酐比, 肾小球滤过率

Abstract: Objective To investigate the relationship between peripheral arterial disease(PAD) and estimated glomerular filtration rate(eGFR) and microalbuminuria(MA) in elderly patients. Methods A total of 328 consecutive patients were included in this study. ABI, Urinary albumin/creatinine ratio(UACR), serum creatinine(Cr), lipids profile, fasting plasma glucose(FPG) and glycosylated hemoglobin(HbA1c) were measured. Cardiovascular risk factors and cardiovascular diseases(CVD) were collected. eGFR was calculated according to Chinese modified MDRD formula based on Cr level. eGFR<60 mL·min^-1·1.73 m^-2 was defined as eGFR reduced. ABI<0.90 was defined as PAD. Results In 328 elderly patients, the prevalence of PAD was 21.0%, 24.4% patients had MA and 25.9% patients had reduced eGFR. Compared to patients without PAD, the Age, levels of SBP, HbA1c, and UACR were significantly increased in patients with PAD(P<0.05 or <0.01). ABI showed a negative correlation with UACR(r = -0.323, P=0.000) and a positive correlation with eGFR(r = 0.185, P=0.001). Logistic regression analysis showed that OR(95% CI) for PAD was 3.613*2.035~6.415) for patients with MA. In models adjusted for age, sex and other traditional cardiovascular risk factors and medicine use, OR(95% CI) for PAD was 2.877(1.588~15.213) for patients with MA. There was no association between eGFR reduction and PAD. Conclusion The prevalence of PAD was higher in elderly patients. MA was associated with PAD, and patients with MA were at a high risk of PAD.

Key words: the elderly patients, ankle brachial index, urinary albumin/creatinine ratio(UACR), estimated glomerular filtration rate