IL-28B 基因多态性对干扰素治疗丙型病毒性肝炎应答的影响

doi:10.3969/j.issn.1006-7795.2012.03.011

首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (3): 334-337.doi: 10.3969/j.issn.1006-7795.2012.03.011

• 丙型肝炎宿主基因型与检测 • 上一篇下一篇

IL-28B 基因多态性对干扰素治疗丙型病毒性肝炎应答的影响

佟小非, 尤红

首都医科大学附属北京友谊医院肝病中心,北京 100050

收稿日期:2012-02-14 修回日期:1900-01-01 出版日期:2012-06-21 发布日期:2012-06-21
通讯作者: 尤红

Genetic polymorphisms of interleukin 28-B play an important role in response to treatment of chronic hepatitis C

TONG Xiao-fei, YOU Hong

Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Received:2012-02-14 Revised:1900-01-01 Online:2012-06-21 Published:2012-06-21

摘要/Abstract

摘要： 目前针对丙型肝炎的标准治疗方案是聚乙二醇干扰素联合利巴韦林。宿主 IL-28B 基因多态性对丙型病毒性肝炎干扰素治疗清除有影响,可以对治疗应答进行预测。本文将从 IL-28B 基因多态性与慢性丙型肝炎治疗应答的关系及其影响应答的可能机制两个方面,对宿主 IL-28B 基因在慢性丙型肝炎治疗实践中的意义进行探讨。

关键词: 丙型病毒性肝炎, 全基因组关联分析, 白细胞介素28B, 干扰素-λ, 干扰素-α

Abstract: The current standard of care for chronic infection with hepatitis C virus is pegylated interferon-alfa(PEG-IFN) and ribavirin (RBV).Genetic variation in interleukin 28-B ( IL-28B ) play an important role in treatment response of chronic hepatitis C. It may be a strong predictor for the therapy of interferon. This paper discusses the significance of IL-28B in the therapy of chronic hepatitis C through the relationship between IL-28B and treatment response with its possible mechanism.

Key words: hepatitis C, genome-wide association study, interleukin 28-B, interferon-λ, interferon-α

中图分类号:

R 512.6⁺3

佟小非;尤红. IL-28B 基因多态性对干扰素治疗丙型病毒性肝炎应答的影响[J]. 首都医科大学学报, 2012, 33(3): 334-337.

TONG Xiao-fei;YOU Hong. Genetic polymorphisms of interleukin 28-B play an important role in response to treatment of chronic hepatitis C[J]. Journal of Capital Medical University, 2012, 33(3): 334-337.

IL-28B 基因多态性对干扰素治疗丙型病毒性肝炎应答的影响

Genetic polymorphisms of interleukin 28-B play an important role in response to treatment of chronic hepatitis C

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