聚丙烯复合脱细胞基质的新型复合补片耐受感染能力的实验研究

doi:10.3969/j.issn.1006-7795.2013.02.022

首都医科大学学报 ›› 2013, Vol. 34 ›› Issue (2): 282-286.doi: 10.3969/j.issn.1006-7795.2013.02.022

聚丙烯复合脱细胞基质的新型复合补片耐受感染能力的实验研究

王明刚, 孙文兵, 杨硕, 田茂霖, 陈杰, 申英末

首都医科大学附属北京朝阳医院疝和腹壁外科, 北京 100043

收稿日期:2013-03-04 出版日期:2013-04-21 发布日期:2013-04-17
通讯作者: 孙文兵 E-mail:wmgonly@126.com
基金资助:
首都医科大学基础-临床科研合作基金项目(12JL40)。

A study on the infection-endurance ability of the novel complex mesh combined by polypropylene and acellular tissue matrix

WANG Minggang, SUN Wenbing, YANG Shuo, TIAN Maolin, CHEN Jie, SHEN Yingmo

Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China

Received:2013-03-04 Online:2013-04-21 Published:2013-04-17
Supported by:
This study was supported by Basic-clinical Cooperative Research Foundation of Capital Medical University(12JL40).

摘要/Abstract

摘要：

目的探讨聚丙烯复合脱细胞基质的新型复合补片在污染环境下耐受感染的能力。方法入组60只实验兔,采用数字表法随机分为2组(n=30),分别以聚丙烯-脱细胞基质复合补片和传统聚丙烯-膨化聚四氟乙烯复合补片进行置入操作(腹腔内疝修补术式,intraperitoneal onlay mesh,IPOM),并以兔结肠液污染补片后关闭切口,术后1个月观察补片感染情况并取补片及周围组织标本,进行病理检查,分析比较2种复合补片在污染环境下耐受感染的能力。结果实验组只有1只实验兔出现补片感染,而对照组有8只兔出现补片感染,病理检查示聚丙烯复合脱细胞基质的新型复合补片易于成纤维细胞的长入及新生血管的生成,两组间比较,差异有统计学意义,感染补片细菌培养结果证实为大肠埃希菌。结论在肠液污染的环境下,聚丙烯复合脱细胞基质的新型复合补片比传统的聚丙烯-膨化聚四氟乙烯复合补片耐受感染的能力更强,其内在的机制可能与新生组织易于长入及新生血管生成有关。

关键词: 复合补片, 感染, 肠液

Abstract:

Objective To explore the infection-endurance ability of the novel complex mesh combined by polypropylene(PP) and acellular tissue matrix(ACTM) in contaminative condition. Methods A total of 60 New Zealand white rabbits were randomized divided into two groups(n=30), the experiment group animals were treated with the novel complex mesh of PP and ACTM(IPOM method) and the control group animals were treated with the traditional complex mesh of PP and expanded polytetrafluoroethy-lene(e-PTFE )(IPOM method) respectively. Meanwhile, the mesh was contaminated with the rabbit intestinal juice in each group before the incision was closed. The infected state of the mesh was observed and specimens for pathological examination were collected during the first month after the operation. Results Only one case of the experiment group and 8 cases of control group appeared infected. It was prone to find fibroblasts proliferation and neovascularization by pathological examination in experiment group. Significant difference was found between the two groups. Through bacterial culture we found Escherichia coli in the infected mesh. Conclusion Compared with the traditional complex mesh of PP and e-PTFE, the novel complex mesh of PP and ACTM had powerful endurance in intestinal juice contaminative condition. The mechanism might be involved in the fibroblast proliferation and neovascularization.

Key words: complex mesh, infection, intestinal juice

中图分类号:

R656.3⁺1

王明刚, 孙文兵, 杨硕, 田茂霖, 陈杰, 申英末. 聚丙烯复合脱细胞基质的新型复合补片耐受感染能力的实验研究[J]. 首都医科大学学报, 2013, 34(2): 282-286.

WANG Minggang, SUN Wenbing, YANG Shuo, TIAN Maolin, CHEN Jie, SHEN Yingmo. A study on the infection-endurance ability of the novel complex mesh combined by polypropylene and acellular tissue matrix[J]. Journal of Capital Medical University, 2013, 34(2): 282-286.

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聚丙烯复合脱细胞基质的新型复合补片耐受感染能力的实验研究

A study on the infection-endurance ability of the novel complex mesh combined by polypropylene and acellular tissue matrix

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