关键词: 人类免疫缺陷病毒, 拔牙术, 抗感染, CD4⁺T淋巴细胞

Abstract: Objective To evaluate the perioperative immune status of human immunodeficiency virus (HIV) patients,and explore the clinical treatment methods to prevent infection and reduce the risk of postoperative infection.Methods Analysis the clinical data of 246 HIV-infected patients for tooth extraction from May 2008 to July 2018. They were divided into three groups according to the level of CD4⁺T lymphocytes before operation,and given corresponding anti-infection treatment. To summarize related perioperative process in each group,and analyze the changes of CD4⁺T lymphocytes for seventh day and 1 month after the operation were done. Results According to the different immune status of patients,we adopted the corresponding anti-infection treatment scheme to ensure the medical safety and achieve the ideal therapeutic result. The results showed that:the CD4⁺T lymphocyte of the patients were significantly reduced 7 days after the operation (P<0.05,with statistical difference),but it could be restored to the preoperative level 1 month after the operation. Conclusion We can determine the operation time,evaluate the operation risk and give corresponding preventive intervention treatment according to CD4⁺T lymphocytes which can reflect the immune status of HIV-infected patients. Reasonable anti-infection treatment can improve the immune status of HIV-infected patients. Meanwhile,the perioperative psychological management and diet management cannot be ignored.

Key words: human immunodeficiency virus (HIV), teeth extraction, anti-infection, CD4⁺T lymphocytes