吸烟对血浆尿酸水平的影响

doi:10.3969/j.issn.1006-7795.2013.06.015

首都医科大学学报 ›› 2013, Vol. 34 ›› Issue (6): 856-859.doi: 10.3969/j.issn.1006-7795.2013.06.015

• 脑血管病的临床和基础研究 • 上一篇下一篇

吸烟对血浆尿酸水平的影响

王玉兰¹, 刘斌², 马丽娜¹, 王蓉¹

1. 首都医科大学宣武医院中心实验室, 北京市老年病医疗研究中心, 北京 100053;
2. 首都医科大学附属北京友谊医院检验科, 北京 100050

收稿日期:2013-10-16 出版日期:2013-12-21 发布日期:2013-12-13
通讯作者: 王蓉 E-mail:rong_wang72@aliyun.com
基金资助:
北京市自然科学基金（7132044）；首都卫生发展科研专项（首发2011-2001-02）。

Effect of cigarette smoking on plasma uric acid concentrations

WANG Yulan¹, LIU Bin², Ma Lina¹, WANG Rong¹

1. Department of Central Laboratory, Xuanwu Hospital, Capital Medical University, Bejing Geriatric Medical Research Center, Bejing 100053, China;
2. Department of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Bejing 100050, China

Received:2013-10-16 Online:2013-12-21 Published:2013-12-13
Supported by:
This study was supported by Natural Science Foundation of Beijing(7132044);Capital Health Development Research(2011-2001-02).

摘要/Abstract

摘要：

目的测定吸烟对血浆尿酸的影响及其与烟草代谢物的关系。方法选取健康体检者300例，其中吸烟者162例（男性145例，女性17例），不吸烟者138例（男性62例，女性76例），测定血浆尿酸、肌酐以及尿可替宁水平。结果吸烟者血浆尿酸水平较不吸烟者明显降低，差异有统计学意义。血浆尿酸水平与吸烟量、吸烟时间呈负相关。结论在排除影响血浆尿酸的因素以后，吸烟者尿酸水平较不吸烟者明显降低，且这种降低与尿酸内源性生成减少有关，是吸烟促发人体应激反应作用的结果。由于血浆尿酸测定方法简单，而且能反映人体的抗氧化物水平，因此它有可能作为了解吸烟应激状态的常规测定指标。

关键词: 吸烟, 可替宁, 尿酸, 氧化应激

Abstract:

Objective The purpose of this study was to examine the effect of cigarette smoking on plasma uric acid concentration and to determine the correlation between this parameter and the biological tobacco markers, urinary cotinine. Methods The study was conducted on 300 subjects. One hundred and thirty-eight of them were nonsmokers(62 men and 76 women) and 162 were current smokers(145 men and 17 women). Uric acid, creatinine, and urinary cotinine were determined by the enzymatic colorimetric method. Results Plasma uric acid concentration was significantly lower in smokers than in nonsmokers. A statistically significant negative correlation was noted between the smoking status parameters, including both the number of cigarettes smoked/day and the duration of smoking, and the plasma uric acid. Among smokers, we noted a negative correlation between uric acid, and urinary cotinine. Conclusion After excluding the other factors affecting the uric acid levels, the significant low plasma uric acid in smokers was attributed to a reduction of the endogenous production as a result of the chronic exposure to cigarette smoke that is a significant source of oxidative stress. Therefore, it is recommended to stop or reduce smoking and to introduce plasma uric acid estimation as a routine test, since it is cheap and simple to reflect the antioxidant level.

Key words: cigarette smoking, cotinine, uric acid, oxidative stress

中图分类号:

R589.2

王玉兰, 刘斌, 马丽娜, 王蓉. 吸烟对血浆尿酸水平的影响[J]. 首都医科大学学报, 2013, 34(6): 856-859.

WANG Yulan, LIU Bin, Ma Lina, WANG Rong. Effect of cigarette smoking on plasma uric acid concentrations[J]. Journal of Capital Medical University, 2013, 34(6): 856-859.

参考文献

[1] Leistikow B N, Tsodikov A. Cancer death epidemics in United States black males: evaluating courses.causation, and cures[J]. Prev Med, 2005, 41(2):380-385.
[2] Mallampalli A, Guntupalli K K. Smoking and systemic disease[J]. Clin Occup Environ Med, 2006, 5(1):173-192.
[3] 马玉玲, 李士玉.吸烟对氧自由基及抗氧化酶活性影响的研究[J].中国行为医学科学杂志, 2001, 10(1):65-67.
[4] van der Vaart H, Postma D S, Timens W, et al. Acute effects of cigarette smoke on inflammation and oxidative stress:a review[J]. Thoras, 2004, 59(8):713-721.
[5] Mathru M, Dries D J, Barnes L, et al. Tourniquet-induced exsanguination in patients requiring lower limb surgery. An ischemia-reperfusion model of oxidant and antioxidant metabolism[J]. Anesthesiology, 1996, 84(1):14-22.
[6] Hellsten Y, Tullson P C, Richter E A, et al. Oxidation of urate in human skeletal muscle during exercise[J]. Free Radic Biol Med, 1997, 22(1-2):169-174.
[7] Meisinger C, Koenig W, Baumert J, et al. Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population:the MONICA/KORA cohort study[J]. Arterioscler Thromb Vasc Biol, 2008, 28(6):1186-1192.
[8] Ioachimescu A G, Brennan D M, Hoar B M, et al. Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system(PreCIS) database cohort study[J]. Arthritis Rheum, 2008, 58(2):365-371.
[9] 孟繁瑞.高尿酸血症对心肌梗死的影响[J].中国煤炭工业医学杂志, 2011, 14(5):669-670.
[10] 邹海洪, 恽景廷.高尿酸血症与心血管病危险因素的关系[J].江苏医药, 2011, 37(18):2221-2222.
[11] 肖强, 李元民, 曾伟.冠心病患者血清尿酸水平与血小板聚集功能的相关性研究[J].泰山医学院学报杂志, 2006, 27(5):402-404.
[12] Kawamoto R, Tomita H, Oka Y, et al. Relationship between serum uric acid concentration. Metabolic syndrome and carotid atherosclerosis[J]. Intern Med, 2006, 45(9):605-614.
[13] Schretlen D J, Inscore A B, Jinnah H A, et al. Serum uric acid and cognitive function in community dwelling older adults[J]. Neuropsychology, 2007, 21(1):136-140.
[14] 蒋莹.北京市健康体检人员血尿酸水平的统计分析[J].中国煤炭工业医学杂志, 2010, 13(2):271.
[15] 谢鹏, 郑秋月, 王立民.军队体检人群高尿酸血症发病情况调查[J].临床误诊误治, 2012, 25(10):72-75.
[16] Waring W S, Convery A, Mishra V, et al. Uric acid reduces exercise-induced oxidative stress in healthy adults[J]. Clin Sci(Lond), 2003, 105(4):425-430.
[17] 杨杰, 姜丽娜, 袁振丽, 等.被动吸烟对子代小鼠学习记忆的影响及抗氧化物干预研究[J].营养学报杂志, 2006, 28(4):314-318.
[18] Waring W S, McKnight J A, Webb D J, et al. Uric acid restores endothelial fuction in patients with type 1 diabetes and regular smoker[J]. Diabetes, 2006, 55(11):3127-3132.

吸烟对血浆尿酸水平的影响

Effect of cigarette smoking on plasma uric acid concentrations

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