多囊卵巢综合征综合治疗对妊娠结局的影响

doi:10.3969/j.issn.1006-7795.2014.04.009

首都医科大学学报 ›› 2014, Vol. 35 ›› Issue (4): 428-432.doi: 10.3969/j.issn.1006-7795.2014.04.009

• 更年期与妇科内分泌专题 • 上一篇下一篇

多囊卵巢综合征综合治疗对妊娠结局的影响

卢永军¹, 阮祥燕¹, 田玄玄¹, 刘玉兰¹, 甄洁¹, Diethelm Wallwiener², Alfred O. Mueck^1,2

1. 首都医科大学附属北京妇产医院内分泌科, 北京 100026;
2. 德国图宾根大学妇产医院内分泌与绝经中心, 德国图宾根 D-72076

收稿日期:2014-06-10 出版日期:2014-08-21 发布日期:2014-07-22
通讯作者: 阮祥燕 E-mail:ruanxiangyan@163.com
基金资助:
国家外专局引智项目（GDJ20141100017），北京市卫生系统高层次卫生技术人才培养计划项目（2009-3-52），首都医科大学附属北京妇产医院北京妇幼保健院学科带头人项目（2013-1）。

Effects of comprehensive treatment for polycystic ovary syndrome（PCOS） on pregnancy outcomes

Lu Yongjun¹, Ruan Xiangyan¹, Tian Xuanxuan¹, Liu Yulan¹, Zhen Jie¹, Diethelm Wallwiener², Alfred O. Mueck^1,2

1. Department of Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
2. Department of Endocrinology, University Women's Hospital of Tubingen, Tubingen D-72076, Germany

Received:2014-06-10 Online:2014-08-21 Published:2014-07-22
Supported by:
This study was supported by China Administration of Foreign Experts Affairs Yinzhi Project(GDJ20141100017); Beijing Municipality Health Technology High-level Talent(2009-3-52); Project of Discipline Leader, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital(2013-1).

摘要/Abstract

摘要：

目的了解多囊卵巢综合征（polycystic ovary syndrome，PCOS）患者综合治疗后对其妊娠结局的影响。方法选取2012年8月~2014年2月就诊于首都医科大学附属北京妇产医院内分泌科被确诊为多囊卵巢综合征且有妊娠要求，并自愿签署知情同意书参加本研究项目的妇女共100例。其中根据是否需要、是否愿意服用炔雌醇环丙孕酮片达英-35和二甲双胍，分为研究组50例和对照组50例。研究组进行3个月个体化综合治疗〔达英-35和（或）二甲双胍联合生活方式调整〕。对照组则仅进行生活方式调整，观察2组的妊娠情况。结果研究组与对照组相比，2组的妊娠率比较，差异无统计学意义（P>0.05）；对照组自然流产6例，妊娠期糖尿病发生5例，妊娠期高血压发生6例；研究组自然流产3例，无妊娠期糖尿病及妊娠期高血压事件发生。2组的自然流产率比较，差异无统计学意义（P>0.05），但研究组与对照组相比自然流产率有降低的趋势。研究组的妊娠期糖尿病、妊娠期高血压发生率均低于对照组（P<0.05）。结论个体化综合治疗对多囊卵巢综合征患者的妊娠有积极作用，可在一定程度上减少妊娠不良结局（如自然流产、妊娠期糖尿病、妊娠期高血压等）的发生。

关键词: 多囊卵巢综合征, 自然流产, 妊娠期糖尿病, 妊娠期高血压

Abstract:

Objective To observe efficacy of comprehensive treatment for polycystic ovary syndrome(PCOS) on pregnancy outcomes.Methods A total of 100 patients with PCOS who were expecting to become pregnant seen in Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University between August 2012 and February 2014 and signed informed consent voluntarily to participate in this research project were enrolled. According to need and willingness of participants to take Diane-35 and metformin, they were divided into observation group(n=50) and control group(n=50). The patients in observation group were treated with individualized comprehensive treatment for 3 months, which included Diane-35 and/or metformin and modification of lifestyle. Control group was only treated with modification of lifestyle. The pregnancy outcomes of two groups were observed. Results 1 The pregnancy rate of 2 groups had no significant difference(P>0.05); 2 The control group had spontaneous abortion in 6 cases, gestational diabetes mellitus in 5 cases and pregnancy induced hypertension in 6 case; the observation group developed spontaneous abortion in 3 cases and had no gestational diabetes mellitus and pregnancy induced hypertension events. The spontaneous abortion rate for two groups had no significant difference(P>0.05), but compared to control group, observation group had a tendency to have lower rate of spontaneous miscarriege. The incidence of gestational diabetes and pregnancy induced hypertension in observation group were lower than those of control group(P<0.05). Conclusion Comprehensive treatment showed a positive role in pregnancy of patients with PCOS and can reduce adverse pregnancy outcomes(e.g. spontaneous abortion, gestational diabetes mellitus, pregnancy induced hypertension) to a certain extent.

Key words: PCOS, spontaneous abortion, gestational diabetes mellitus, pregnancy induced hypertension

中图分类号:

R711.75

卢永军, 阮祥燕, 田玄玄, 刘玉兰, 甄洁, Diethelm Wallwiener, Alfred O. Mueck. 多囊卵巢综合征综合治疗对妊娠结局的影响[J]. 首都医科大学学报, 2014, 35(4): 428-432.

Lu Yongjun, Ruan Xiangyan, Tian Xuanxuan, Liu Yulan, Zhen Jie, Diethelm Wallwiener, Alfred O. Mueck. Effects of comprehensive treatment for polycystic ovary syndrome（PCOS） on pregnancy outcomes[J]. Journal of Capital Medical University, 2014, 35(4): 428-432.

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多囊卵巢综合征综合治疗对妊娠结局的影响

Effects of comprehensive treatment for polycystic ovary syndrome（PCOS） on pregnancy outcomes

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