糖耐量减低人群工作记忆的脑功能磁共振成像研究

doi:10.3969/j.issn.1006-7795.2015.01.018

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (1): 94-97.doi: 10.3969/j.issn.1006-7795.2015.01.018

• 糖尿病前期与神经病变 • 上一篇下一篇

糖耐量减低人群工作记忆的脑功能磁共振成像研究

吴小娟¹, 庄晓明¹, 何悦明², 盛树力³

1. 首都医科大学附属复兴医院内分泌科, 北京 100038;
2. 首都医科大学附属复兴医院放射科, 北京 100038;
3. 首都医科大学宣武医院中心实验室, 北京 100053

收稿日期:2014-09-01 出版日期:2015-02-21 发布日期:2015-01-31
通讯作者: 庄晓明 E-mail:zhuangxiaoming101@163.com
基金资助:
北京市西城区科技计划项目(2012JH29).

A study on working memory of patients with impaired glucose tolerance by functional magnetic resonance imaging technique

Wu Xiaojuan¹, Zhuang Xiaoming¹, He Yueming², Sheng Shuli³

1. Department of Endocrinology, Fuxing Hospital, Capital Medical University, Beijing 100038, China;
2. Department of Radiology, Fuxing Hospital, Capital Medical University, Beijing 100038, China;
3. Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

Received:2014-09-01 Online:2015-02-21 Published:2015-01-31
Supported by:
This study was supported by Xicheng District, Beijing Science and Technology Project(2012JH29).

摘要/Abstract

摘要： 目的探讨糖耐量减低的认知功能以及在特定任务刺激下不同脑区的活动情况.方法对13例糖耐量减低(impaired glucose tolerance,IGT)患者和19名糖耐量正常(normal glucose tolerance,NGT)受试者进行认知、记忆评估及词语(文字、数字)工作记忆及客体(面孔)工作记忆任务下的功能性磁共振检查,分析脑激活图.结果 ①IGT患者的认知与NGT组相比,差异无统计学意义(t=0.459,P=0.635).②与NGT组相比,IGT组在文字工作记忆中右侧颞叶、颞上回(brodmann area 22,BA22区)等脑区激活减弱(t=55.81,P=0.009);数字工作记忆中,右侧豆状核、壳核等脑区激活减弱(t=216.84, P=0.009);客体工作记忆中:右侧尾状核体激活减弱(t=5.09,P=0.008).结论 IGT患者词语及客体工作记忆经典激活脑区可能存在损害.

关键词: 糖耐量减低, 工作记忆, 功能性磁共振成像

Abstract: Objective To investigate the working memory in the patients with impaired glucose tolerance (IGT) by functional magnetic resonance imaging (fMRI). Methods Verbal and objective working memory tasks were performed in 13 patients with IGT and 19 persons with normal glucose tolerance (NGT) while performing fMRI. The cognitive function, memory function and the activation map were analyzed.Results ① There was no significant difference in cognition function between the NGT and IGT group (t=0.459, P=0.635). ②Compared with NGT group, there was less activation of right temporal and superior temporal gyrus (BA22) area in IGT group during word working memory; less activation of right putamen, lenticular body in IGT group during number working memory; less activation of right caudate body in IGT group during object working memory (P<0.01). Conclusion IGT group may have lesions in the classic activation areas during verbal working memory and object memory.

Key words: impaired glucose tolerance, working memory, functional magnetic resonance imaging

中图分类号:

吴小娟, 庄晓明, 何悦明, 盛树力. 糖耐量减低人群工作记忆的脑功能磁共振成像研究[J]. 首都医科大学学报, 2015, 36(1): 94-97.

Wu Xiaojuan, Zhuang Xiaoming, He Yueming, Sheng Shuli. A study on working memory of patients with impaired glucose tolerance by functional magnetic resonance imaging technique[J]. Journal of Capital Medical University, 2015, 36(1): 94-97.

参考文献

[1] Yang S H, Dou K F, Song W J, et al. Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010,362(25):2425-2426.
[2] Alberti K G, Zimmet P Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation[J]. Diabet Med,1998,15(7):539-553.
[3] 温洪波, 张振馨, 牛富生, 等. 北京地区蒙特利尔认知量表的应用研究[J]. 中华内科杂志, 2008,47(1):36-39.
[4] Bacha F, Gungor N, Lee S, et al. In Vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?[J]. Diabetes Care, 2009,32(1):100-105.
[5] Lamport D J, Lawton C L, Mansfield M W, et al. Impairments in glucose tolerance can have a negative impact on cognitive function: a systematic research review[J]. Neurosci Biobehav Rev, 2009,33(3):394-413.
[6] Staffen W, Schonauer U, Zauner H, et al. Brain perfusion SPECT in patients with mild cognitive impairment and Alzheimer's disease: comparison of a semiquantitative and a visual evaluation[J]. J Neural Transm, 2006,113(2):195-203.
[7] Thambisetty M, Beason-Held L L, An Y, et al. Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging[J]. Neurobiol Aging, 2013,34(10):2271-2276.
[8] Zhou H, Lu W, Shi Y, et al. Impairments in cognition and resting-state connectivity of the hippocampus in elderly subjects with type 2 diabetes[J]. Neurosci Lett, 2010,473(1):5-10.
[9] 庄晓明,盛树力.糖尿病和散发性老年痴呆[J].中华内科杂志, 2007, 46(11):948-949.
[10] 崔黎黎,赵传胜.2型糖尿病患者胰岛素抵抗与合并周围神经病变的相关性分析[J]. 中国医科大学学报,2012,41(8):734-737.
[11] Gonzales M M, Tarumi T, Miles S C, et al. Insulin sensitivity as a mediator of the relationship between BMI and working memory-related brain activation[J]. Obesity:Silver Spring, 2010,18(11):2131-2137.
[12] 齐中华, 李胜,梁战华,等.认知功能障碍与2型糖尿病的临床相关分析及危险因素筛查[J]. 中国医科大学学报,2013,42(8):702-706.
[13] Hoth K F, Gonzales M M, Tarumi T, et al. Functional MR imaging evidence of altered functional activation in metabolic syndrome[J]. AJNR Am J Neuroradiol, 2011,32(3):541-547.

[1]	苏志燕, 刘薇, 史婷婷. 老年2型糖尿病患者血尿酸浓度与代谢综合征的相关性分析[J]. 首都医科大学学报, 2023, 44(1): 137-142.
[2]	郭月红, 黄京伟, 常玉婷, 杨敏福. ^99mTc-MIBI平面显像及断层显像诊断原发性甲状旁腺功能亢进的效能评价[J]. 首都医科大学学报, 2022, 43(6): 873-879.
[3]	王华, 史婷婷, 信中, 华琳, 李聪, 曹秋梅. Graves病患者促甲状腺素受体抗体与肠道菌群及短链脂肪酸的相关性[J]. 首都医科大学学报, 2022, 43(6): 931-939.
[4]	安宇, 边南南, 丁小雨, 常晓娜, 刘佳, 王广. 1型糖尿病伴认知功能损伤小鼠脑组织肠道菌群代谢物的改变[J]. 首都医科大学学报, 2022, 43(4): 622-629.
[5]	修双玲, 付俊玲, 穆志静, 孙丽娜, 赵蕾. 老年2型糖尿病患者体脂率对肌力和躯体功能的影响[J]. 首都医科大学学报, 2022, 43(4): 641-646.
[6]	宋丽敏, 李思源, 李军, 赵会荣, 李佳佳, 王双. 新疆石河子地区绝经后2型糖尿病女性SOST基因联合LRP5基因多态性及突变与骨代谢关系的研究[J]. 首都医科大学学报, 2022, 43(2): 269-274.
[7]	修双玲, 孙丽娜, 穆志静, 付俊玲, 赵蕾. 不同方法校正的肌肉质量与老年2型糖尿病躯体功能的相关性比较[J]. 首都医科大学学报, 2022, 43(2): 284-288.
[8]	姚舒洋, 李小雪, 王淳秀, 张毅. 埃克替尼联合抗血管药物一线治疗EGFR突变晚期肺腺癌的单中心研究[J]. 首都医科大学学报, 2022, 43(2): 289-293.
[9]	熊枫然, 卢晶, 张英超, 谢荣荣, 赵儒轩, 李奇, 杨金奎. Kcnh6点突变单基因糖尿病家系的小鼠模型构建及表型分析[J]. 首都医科大学学报, 2021, 42(4): 575-581.
[10]	李志, 张郡, 戴悦萱, 秦明阳, 梁芙茹. 血糖波动对2型糖尿病大鼠认知功能的影响[J]. 首都医科大学学报, 2021, 42(3): 347-353.
[11]	米颖馨, 王欣, 张开, 李可悦, 孙丽娜, 修双玲. 中老年男性2型糖尿病患者尿酸水平与肌少症的相关性研究[J]. 首都医科大学学报, 2021, 42(3): 453-458.
[12]	郑爽爽, 高志远, 宋双双, 何悦明, 卢洁. BOLD MRI评价糖尿病患者尿微量白蛋白及氧合水平的研究[J]. 首都医科大学学报, 2021, 42(1): 125-130.
[13]	李响, 蒲连美, 阮杨, 李红, 金泽宁. 汉族人群ADIPOR1 rs7539542与冠状动脉粥样硬化性心脏病和2型糖尿病的关联分析[J]. 首都医科大学学报, 2020, 41(6): 935-942.
[14]	尹星琪, 于彩果, 柯静, 赵冬, 于可. 2型糖尿病患者新型冠状病毒肺炎流行期间心理状态及行为调查[J]. 首都医科大学学报, 2020, 41(6): 970-977.
[15]	卢晶, 杨卫利, 杨芳远, 曹曦, 杨金奎. 医学研究的凿光探秘者——杨金奎教授[J]. 首都医科大学学报, 2020, 41(5): 849-853.

糖耐量减低人群工作记忆的脑功能磁共振成像研究

A study on working memory of patients with impaired glucose tolerance by functional magnetic resonance imaging technique

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价