细胞基因组

doi:10.3969/j.issn.1006-7795.2015.05.032

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (5): 823-828.doi: 10.3969/j.issn.1006-7795.2015.05.032

细胞基因组"维稳"的DNA修复机制——2015年诺贝尔化学奖介绍

孔璐, 丁卫

首都医科大学基础医学院生物化学与分子生物学系, 北京 100069

收稿日期:2015-10-12 出版日期:2015-10-21 发布日期:2015-10-20

Mechanisms of DNA repair for the maintenance of genome stability in cells——introduction of 2015 Nobel Prize in Chemistry

Kong Lu, Ding Wei

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

Received:2015-10-12 Online:2015-10-21 Published:2015-10-20
Contact: 丁卫 E-mail:weiding@ccmu.edu.cn

摘要/Abstract

摘要： 2015年诺贝尔化学奖授予了瑞典的托马斯·林道尔(Tomas Lindahl)、美国的保罗·莫德里奇(Paul Modrich)和美国/土耳其双国籍科学家阿奇兹·桑贾尔(Aziz Sancar),以表彰他们对揭示细胞DNA修复机制的贡献。本文就3位获奖者的研究成果及其学术意义进行了介绍和总结,同时鉴于DNA修复与细胞基因组稳定性以及人类疾病的密切联系,特别就高通量序列分析和组学研究对相关领域的影响和前景进行了分析和探讨。

关键词: 诺贝尔化学奖, DNA修复, 基因组稳定性, 高通量序列分析

Abstract: The 2015 Nobel Prize in Chemistry was honored to three scientists of Tomas Lindahl from Sweden, Paul Modrich from United States and Aziz Sancar with both American and Turkish nationalities for their contributions in revealing the mechanisms of DNA repair in cells. This article overviewed their research discoveries with the highlighted significance. Meanwhile, as DNA repair is closely connected to cell genome stability, especially under disease conditions, we commented the impact and perspective of high-throughput sequencing and the omic technologies on the future studies in biomedical fields.

Key words: Nobel Prize in Chemistry, DNA repair, genome stability, high-throughput sequencing

孔璐, 丁卫. 细胞基因组"维稳"的DNA修复机制——2015年诺贝尔化学奖介绍[J]. 首都医科大学学报, 2015, 36(5): 823-828.

Kong Lu, Ding Wei. Mechanisms of DNA repair for the maintenance of genome stability in cells——introduction of 2015 Nobel Prize in Chemistry[J]. Journal of Capital Medical University, 2015, 36(5): 823-828.

参考文献

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细胞基因组"维稳"的DNA修复机制——2015年诺贝尔化学奖介绍

Mechanisms of DNA repair for the maintenance of genome stability in cells——introduction of 2015 Nobel Prize in Chemistry

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