关键词: 高分辨度晶体解析, 核蛋白体, 诺贝尔化学奖

Abstract: "What you see is what you learn" is believed to be the essence of the structural biology research. In the 2009 Nobel Prize in Chemistry awarded work, three outstanding scientists from the United States and Israel have vividly demonstrated that how high-resolution crystallography not only helped to solve long-standing problems in the structural-functional studies for the roles of ribosomes in the process of protein biosynthesis, but also revealed the underlying mechanisms. Their contributions have provided far-reaching implications for basic biological and medical sciences, and meanwhile inspired and expanded the important applications for related drug development, such as the designs of antibiotics.

Key words: high-resolution crystallography, ribosome, Nobel Prize in Chemistry