资癸女贞胶囊治疗复发性流产的疗效观察

doi:10.3969/j.issn.1006-7795.2016.05.025

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (5): 688-692.doi: 10.3969/j.issn.1006-7795.2016.05.025

资癸女贞胶囊治疗复发性流产的疗效观察

李嘉音¹, 李扬璐², 阮祥燕², 李玉林¹, 刘敏如³

1. 吉林大学基础医学院病理生物学教育部重点实验室, 长春 130012;
2. 首都医科大学附属北京妇产医院内分泌科, 北京 100026;
3. 成都中医药大学妇科教研室, 成都 610075

收稿日期:2016-09-09 出版日期:2016-10-21 发布日期:2016-10-19
通讯作者: 阮祥燕 E-mail:ruanxiangyan@163.com
基金资助:
首都临床特色应用研究与成果推广（Z161100000516143），首都卫生发展科研专项项目（2016-2-2113），北京市卫生系统高层次卫生技术人才（学科带头人）（2014-2-016）。

Effects of Zi Gui Nv Zhen capsule on recurrent spontaneous abortion

Li Jiayin¹, Li Yanglu², Ruan Xiangyan², Li Yulin¹, Liu Minru³

1. The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jinlin University, Changchun 130012, China;
2. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
3. Teaching and Research Section of Department of Gynecology, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

Received:2016-09-09 Online:2016-10-21 Published:2016-10-19
Supported by:
This study was supported by Capital Characteristic Clinic Project of China(Z161100000516143); Beijing Capital Foundation for Medical Science Development and Research(2016-2-2113); Beijing Municipality Health Technology High-Level Talent (2014-2-016).

摘要/Abstract

摘要： 目的观察资癸女贞胶囊对复发性流产的疗效。方法 76例复发性流产患者采用数字表法随机分为研究组（n=45）和对照组（n=31）。对照组单纯应用雌二醇贴片，研究组联合雌二醇贴片和资癸女贞胶囊，治疗3个月期间监测排卵后子宫内膜螺旋动脉血流搏动指数、阻力指数、子宫内膜厚度及类型、黄体期孕酮和雌二醇浓度，随访1年后的妊娠和活产情况。结果研究组子宫内膜厚度显著高于对照组（P<0.05），A型内膜数目明显增多（P<0.05），排卵日子宫内膜血流搏动指数和阻力指数显著低于对照组（P<0.05）；1年后随访，研究组临床妊娠率和活产率显著高于对照组（P<0.05）。结论雌二醇贴片联合资癸女贞胶囊可显著改善复发性流产患者的子宫内膜血供，优化内膜厚度和类型，改善黄体功能，提高子宫内膜容受性，提高这类患者的临床妊娠率和活产率，为复发性流产的治疗提供了新途径。

关键词: 复发性流产, 资癸女贞胶囊, 子宫内膜容受性, 临床妊娠率, 活产率

Abstract: Objective To observe the effects of Zi Gui Nv Zhen capsule on recurrent spontaneous abortion (RSA). Methods Seventy-six RSA patients were divided into study group (n=45) and control group(n=31) randomly. The patients in the study group were treated with estradiolhemihydrates patches combined with Zi Gui Nv Zhen capsules, and the those in control group were treated with estradiolhemihydratepatches alone. Both groups were treated for 3 cycles. The endometrium thickness and type, the pulsation index (PI) and resistance index (RI) of uterine helicine artery blood flow after ovulation were monitored, serum estradiol and progesterone were detected in luteal phase. The clinical pregnancy rate and live birth rate were followed up. Results After treatment for 3 cycles, the study group obtained more type A endometrium, lower PI and RI significantly, and the endometrium thickness in study group increases more than that in control group significantly. After one year, the study group obtained higher clinical pregnancy rate and live birth rate significantly. Conclusion Estradiolhemihydratepatches combined with Zi Gui Nv Zhen capsule can improve the endometrial blood flow and corpus luteum function, optimize the type of endometrium in RSA patients, improve the endometrium receptivity, and increase their pregnancy rate and live birth rate. It indicates that Estradiolhemihydratepatches combined with Zi Gui Nv Zhen capsule provide new treatment method for RSA patients.

Key words: recurrent spontaneous abortion, Zi Gui Nv Zhen capsule, endometrium receptivity, clinical pregnancy rate, livebirth rate

中图分类号:

R714.21

李嘉音, 李扬璐, 阮祥燕, 李玉林, 刘敏如. 资癸女贞胶囊治疗复发性流产的疗效观察[J]. 首都医科大学学报, 2016, 37(5): 688-692.

Li Jiayin, Li Yanglu, Ruan Xiangyan, Li Yulin, Liu Minru. Effects of Zi Gui Nv Zhen capsule on recurrent spontaneous abortion[J]. Journal of Capital Medical University, 2016, 37(5): 688-692.

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资癸女贞胶囊治疗复发性流产的疗效观察

Effects of Zi Gui Nv Zhen capsule on recurrent spontaneous abortion

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